LRP3_HUMAN » Low-density lipoprotein receptor-related protein 3

LRP3_HUMAN » Low-density lipoprotein receptor-related protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRP3_HUMAN » Low-density lipoprotein receptor-related protein 3 » LRP-3; 105 kDa low-density lipoprotein receptor-related protein;hLRp105;
Hydrophobic Thickness 33.6 ± 6.6 Å
Tilt Angle 42 ± 2°
ΔGtransfer -23.6 kcal/mol
ΔGfold -19.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 492-521 (492-527)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 43-156, PDBID: 1NT0, Subunit A, Seq Identity:32%, CUB domain

AA: 164-200, PDBID: 2M0P, Subunit A, Seq Identity:53%, Low-density lipoprotein receptor domain class A

AA: 210-249, PDBID: 1F5Y, Subunit A, Seq Identity:51%, Low-density lipoprotein receptor domain class A

AA: 254-362, PDBID: 1SPP, Subunit A, Seq Identity:26%, CUB domain

AA: 453-489, PDBID: 1F5Y, Subunit A, Seq Identity:56%, Low-density lipoprotein receptor domain class A

UniProt annotation for LRP3_HUMAN » Low-density lipoprotein receptor-related protein 3
FUNCTION: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.

SUBUNIT: Binds GGA1 and GGA2.

TISSUE SPECIFICITY: Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte.

UniProt features for LRP3_HUMAN » Low-density lipoprotein receptor-related protein 3
SIGNAL 1 36 Potential.
CHAIN 37 770 Low-density lipoprotein receptor-related protein 3.
DOMAIN 43 159 CUB 1.
DOMAIN 165 201 LDL-receptor class A 1.
DOMAIN 211 250 LDL-receptor class A 2.
DOMAIN 254 365 CUB 2.
DOMAIN 415 453 LDL-receptor class A 3.
DOMAIN 454 490 LDL-receptor class A 4.
DISULFID 43 72 By similarity.
DISULFID 99 120 By similarity.
DISULFID 166 178 By similarity.
DISULFID 173 191 By similarity.
DISULFID 185 200 By similarity.
DISULFID 212 227 By similarity.
DISULFID 219 240 By similarity.
DISULFID 234 249 By similarity.
DISULFID 254 282 By similarity.
DISULFID 416 430 By similarity.
DISULFID 423 443 By similarity.
DISULFID 437 452 By similarity.
DISULFID 455 467 By similarity.
DISULFID 462 480 By similarity.
DISULFID 474 489 By similarity.
Amino Acid Sequence for LRP3_HUMAN » Low-density lipoprotein receptor-related protein 3
MEKRAAAGLE GAPGARAQLA VVCLVNIFLT GRLSSAVPAL AACSGKLEQH TERRGVIYSP AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS LDWLLLGPAA PPRQEAFRLC GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ GFRLSYIRGK LGQASCQADE FRCDNGKCLP GPWQCNTVDE CGDGSDEGNC SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGLQDC GDGSDEAGCP DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD SRRVLLQLEL RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR ARSAGHGFNA TYQVKGYCLP WEQPCGSSSD SDGGSLGDQG CFSEPQRCDG WWHCASGRDE QGCPACPPDQ YPCEGGSGLC YTPADRCNNQ KSCPDGADEK NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC QDGSDEHGCL AAVPRKVITA ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL EAEFVRREAP PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS RRRLGRLWNR LFHRPRAPRG QIPLLTAARP SQTVLGDGFL QPAPGAAPDP PAPLMDTGST RAAGDRPPSA PGRAPEVGPS GPPLPSGLRD PECRPVDKDR KVCREPLVDG PAPADAPREP CSAQDPHPQV STASSTLGPH SPEPLGVCRN PPPPCSPMLE ASDDEALLVC