LRP1_HUMAN » Prolow-density lipoprotein receptor-related protein 1

LRP1_HUMAN » Prolow-density lipoprotein receptor-related protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRP1_HUMAN » Prolow-density lipoprotein receptor-related protein 1 » LRP-1; Alpha-2-macroglobulin receptor;A2MR; Apolipoprotein E receptor;APOER;
Hydrophobic Thickness 34.0 ± 0.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -53.7 kcal/mol
ΔGfold -26.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 4420-4445 (4420-4447)
Pathways

Alzheimer's disease (KEGG)

Binding and Uptake of Ligands by Scavenger Receptors (Reactome)

Malaria (KEGG)

RNA degradation (KEGG)

Signal Transduction (Reactome)

PDB 1j8e (1011-1054), 1cr8 (1059-1100), 2knx (2770-2817), 2kny (2770-2817), 1d2l (851-893), 2fyj (932-1013), 2fyl (B=932-1013)
OPM none
Complexes none
Interactions

A4, Complex: LRP1:A4, PubMed

BACE1, Complex: LRP1:BACE1, PubMed

CALX, Complex: CALX:LRP1, PubMed

EGFR, Complex: EGFR:LRP1, PubMed

FURIN, Complex: FURIN:LRP1, PubMed

MMP14, Complex: MMP14:LRP1, PubMed

MMP15, Complex: MMP15:LRP1, PubMed

MMP16, Complex: MMP16:LRP1, PubMed

NOTC3, Complex: LRP1:NOTC3, PubMed

SYJ2B, Complex: SYJ2B:LRP1, PubMed

Domains

AA: 25-64, PDBID: 2FCW, Subunit B, Seq Identity:53%, Low-density lipoprotein receptor domain class A

AA: 25-64, PDBID: 1N7D, Subunit A, Seq Identity:53%, Low-density lipoprotein receptor domain class A

AA: 70-108, PDBID: 2KNX, Subunit A, Seq Identity:44%, Low-density lipoprotein receptor domain class A

AA: 150-188, PDBID: 1UZJ, Subunit B, Seq Identity:48%, Calcium-binding EGF domain

AA: 614-657, PDBID: 3S94, Subunit B, Seq Identity:51%, Low-density lipoprotein receptor repeat class B

AA: 660-708, PDBID: 3S94, Subunit B, Seq Identity:48%, Low-density lipoprotein receptor repeat class B

AA: 807-842, PDBID: 3S94, Subunit A, Seq Identity:48%, Coagulation Factor Xa inhibitory site

AA: 852-890, PDBID: 1D2L, Subunit A, Seq Identity:100%, Low-density lipoprotein receptor domain class A

AA: 893-931, PDBID: 1J8E, Subunit A, Seq Identity:60%, Low-density lipoprotein receptor domain class A

AA: 934-971, PDBID: 2FYJ, Subunit A, Seq Identity:100%, Low-density lipoprotein receptor domain class A

AA: 974-1011, PDBID: 2FYJ, Subunit A, Seq Identity:100%, Low-density lipoprotein receptor domain class A

AA: 1013-1051, PDBID: 1J8E, Subunit A, Seq Identity:100%, Low-density lipoprotein receptor domain class A

AA: 1060-1097, PDBID: 1CR8, Subunit A, Seq Identity:100%, Low-density lipoprotein receptor domain class A

AA: 1102-1140, PDBID: 2M0P, Subunit A, Seq Identity:52%, Low-density lipoprotein receptor domain class A

AA: 1185-1221, PDBID: 3S94, Subunit A, Seq Identity:52%, Coagulation Factor Xa inhibitory site

AA: 1356-1396, PDBID: 3S94, Subunit B, Seq Identity:53%, Low-density lipoprotein receptor repeat class B

AA: 1399-1443, PDBID: 3V64, Subunit D, Seq Identity:50%, Low-density lipoprotein receptor repeat class B

AA: 1627-1667, PDBID: 3V64, Subunit D, Seq Identity:54%, Low-density lipoprotein receptor repeat class B

AA: 1977-2017, PDBID: 3S94, Subunit B, Seq Identity:58%, Low-density lipoprotein receptor repeat class B

AA: 2020-2061, PDBID: 3S94, Subunit B, Seq Identity:62%, Low-density lipoprotein receptor repeat class B

AA: 2344-2386, PDBID: 3S94, Subunit B, Seq Identity:45%, Low-density lipoprotein receptor repeat class B

AA: 2389-2428, PDBID: 1IJQ, Subunit A, Seq Identity:41%, Low-density lipoprotein receptor repeat class B

AA: 2522-2561, PDBID: 1AJJ, Subunit A, Seq Identity:52%, Low-density lipoprotein receptor domain class A

AA: 2564-2600, PDBID: 3T5O, Subunit A, Seq Identity:51%, Low-density lipoprotein receptor domain class A

AA: 2603-2639, PDBID: 1AJJ, Subunit A, Seq Identity:51%, Low-density lipoprotein receptor domain class A

AA: 2657-2688, PDBID: 2XRC, Subunit D, Seq Identity:47%, Low-density lipoprotein receptor domain class A

AA: 2694-2730, PDBID: 2FYJ, Subunit A, Seq Identity:57%, Low-density lipoprotein receptor domain class A

AA: 2732-2769, PDBID: 2M0P, Subunit A, Seq Identity:56%, Low-density lipoprotein receptor domain class A

AA: 2772-2812, PDBID: 2KNX, Subunit A, Seq Identity:100%, Low-density lipoprotein receptor domain class A

AA: 2816-2853, PDBID: 2KNY, Subunit A, Seq Identity:100%, Low-density lipoprotein receptor domain class A

AA: 2856-2897, PDBID: 1D2L, Subunit A, Seq Identity:58%, Low-density lipoprotein receptor domain class A

AA: 2902-2939, PDBID: 3T5O, Subunit A, Seq Identity:57%, Low-density lipoprotein receptor domain class A

AA: 2962-2985, PDBID: 3V65, Subunit D, Seq Identity:53%, Complement Clr-like EGF-like

AA: 3022-3258, PDBID: 3S25, Subunit A, Seq Identity:8%, Domain of unknown function (DUF5050)

AA: 3294-3330, PDBID: 3S94, Subunit A, Seq Identity:57%, Coagulation Factor Xa inhibitory site

AA: 3332-3369, PDBID: 3A7Q, Subunit B, Seq Identity:55%, Low-density lipoprotein receptor domain class A

AA: 3372-3408, PDBID: 2FYJ, Subunit A, Seq Identity:55%, Low-density lipoprotein receptor domain class A

AA: 3411-3448, PDBID: 1F5Y, Subunit A, Seq Identity:45%, Low-density lipoprotein receptor domain class A

AA: 3451-3489, PDBID: 1N7D, Subunit A, Seq Identity:57%, Low-density lipoprotein receptor domain class A

AA: 3492-3531, PDBID: 1CR8, Subunit A, Seq Identity:53%, Low-density lipoprotein receptor domain class A

AA: 3534-3570, PDBID: 2FYJ, Subunit A, Seq Identity:61%, Low-density lipoprotein receptor domain class A

AA: 3573-3609, PDBID: 1AJJ, Subunit A, Seq Identity:56%, Low-density lipoprotein receptor domain class A

AA: 3611-3647, PDBID: 1CR8, Subunit A, Seq Identity:60%, Low-density lipoprotein receptor domain class A

AA: 3652-3690, PDBID: 2FYJ, Subunit A, Seq Identity:52%, Low-density lipoprotein receptor domain class A

AA: 3739-3776, PDBID: 3A7Q, Subunit B, Seq Identity:52%, Low-density lipoprotein receptor domain class A

AA: 3824-3861, PDBID: 1Z6C, Subunit A, Seq Identity:39%, Calcium-binding EGF domain

AA: 3970-4010, PDBID: 3S94, Subunit B, Seq Identity:58%, Low-density lipoprotein receptor repeat class B

AA: 4013-4054, PDBID: 3S94, Subunit B, Seq Identity:60%, Low-density lipoprotein receptor repeat class B

AA: 4057-4099, PDBID: 1IJQ, Subunit A, Seq Identity:41%, Low-density lipoprotein receptor repeat class B

UniProt annotation for LRP1_HUMAN » Prolow-density lipoprotein receptor-related protein 1
FUNCTION: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.

FUNCTION: Functions as a receptor for Pseudomonas aeruginosa exotoxin A.

SUBUNIT: Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa N-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1. Interacts with LRPAP1. Can weakly interact (via NPXY motif) with DAB2 (via PID domain); the interaction is enhanced by tyrosine phosphorylation of the NPXY motif. Interacts with bacterial exotoxins.

TISSUE SPECIFICITY: Most abundant in liver, brain and lung.

Amino Acid Sequence for LRP1_HUMAN » Prolow-density lipoprotein receptor-related protein 1
MLTPPLLLLL PLLSALVAAA IDAPKTCSPK QFACRDQITC ISKGWRCDGE RDCPDGSDEA PEICPQSKAQ RCQPNEHNCL GTELCVPMSR LCNGVQDCMD GSDEGPHCRE LQGNCSRLGC QHHCVPTLDG PTCYCNSSFQ LQADGKTCKD FDECSVYGTC SQLCTNTDGS FICGCVEGYL LQPDNRSCKA KNEPVDRPPV LLIANSQNIL ATYLSGAQVS TITPTSTRQT TAMDFSYANE TVCWVHVGDS AAQTQLKCAR MPGLKGFVDE HTINISLSLH HVEQMAIDWL TGNFYFVDDI DDRIFVCNRN GDTCVTLLDL ELYNPKGIAL DPAMGKVFFT DYGQIPKVER CDMDGQNRTK LVDSKIVFPH GITLDLVSRL VYWADAYLDY IEVVDYEGKG RQTIIQGILI EHLYGLTVFE NYLYATNSDN ANAQQKTSVI RVNRFNSTEY QVVTRVDKGG ALHIYHQRRQ PRVRSHACEN DQYGKPGGCS DICLLANSHK ARTCRCRSGF SLGSDGKSCK KPEHELFLVY GKGRPGIIRG MDMGAKVPDE HMIPIENLMN PRALDFHAET GFIYFADTTS YLIGRQKIDG TERETILKDG IHNVEGVAVD WMGDNLYWTD DGPKKTISVA RLEKAAQTRK TLIEGKMTHP RAIVVDPLNG WMYWTDWEED PKDSRRGRLE RAWMDGSHRD IFVTSKTVLW PNGLSLDIPA GRLYWVDAFY DRIETILLNG TDRKIVYEGP ELNHAFGLCH HGNYLFWTEY RSGSVYRLER GVGGAPPTVT LLRSERPPIF EIRMYDAQQQ QVGTNKCRVN NGGCSSLCLA TPGSRQCACA EDQVLDADGV TCLANPSYVP PPQCQPGEFA CANSRCIQER WKCDGDNDCL DNSDEAPALC HQHTCPSDRF KCENNRCIPN RWLCDGDNDC GNSEDESNAT CSARTCPPNQ FSCASGRCIP ISWTCDLDDD CGDRSDESAS CAYPTCFPLT QFTCNNGRCI NINWRCDNDN DCGDNSDEAG CSHSCSSTQF KCNSGRCIPE HWTCDGDNDC GDYSDETHAN CTNQATRPPG GCHTDEFQCR LDGLCIPLRW RCDGDTDCMD SSDEKSCEGV THVCDPSVKF GCKDSARCIS KAWVCDGDND CEDNSDEENC ESLACRPPSH PCANNTSVCL PPDKLCDGND DCGDGSDEGE LCDQCSLNNG GCSHNCSVAP GEGIVCSCPL GMELGPDNHT CQIQSYCAKH LKCSQKCDQN KFSVKCSCYE GWVLEPDGES CRSLDPFKPF IIFSNRHEIR RIDLHKGDYS VLVPGLRNTI ALDFHLSQSA LYWTDVVEDK IYRGKLLDNG ALTSFEVVIQ YGLATPEGLA VDWIAGNIYW VESNLDQIEV AKLDGTLRTT LLAGDIEHPR AIALDPRDGI LFWTDWDASL PRIEAASMSG AGRRTVHRET GSGGWPNGLT VDYLEKRILW IDARSDAIYS ARYDGSGHME VLRGHEFLSH PFAVTLYGGE VYWTDWRTNT LAKANKWTGH NVTVVQRTNT QPFDLQVYHP SRQPMAPNPC EANGGQGPCS HLCLINYNRT VSCACPHLMK LHKDNTTCYE FKKFLLYARQ MEIRGVDLDA PYYNYIISFT VPDIDNVTVL DYDAREQRVY WSDVRTQAIK RAFINGTGVE TVVSADLPNA HGLAVDWVSR NLFWTSYDTN KKQINVARLD GSFKNAVVQG LEQPHGLVVH PLRGKLYWTD GDNISMANMD GSNRTLLFSG QKGPVGLAID FPESKLYWIS SGNHTINRCN LDGSGLEVID AMRSQLGKAT ALAIMGDKLW WADQVSEKMG TCSKADGSGS VVLRNSTTLV MHMKVYDESI QLDHKGTNPC SVNNGDCSQL CLPTSETTRS CMCTAGYSLR SGQQACEGVG SFLLYSVHEG IRGIPLDPND KSDALVPVSG TSLAVGIDFH AENDTIYWVD MGLSTISRAK RDQTWREDVV TNGIGRVEGI AVDWIAGNIY WTDQGFDVIE VARLNGSFRY VVISQGLDKP RAITVHPEKG YLFWTEWGQY PRIERSRLDG TERVVLVNVS ISWPNGISVD YQDGKLYWCD ARTDKIERID LETGENREVV LSSNNMDMFS VSVFEDFIYW SDRTHANGSI KRGSKDNATD SVPLRTGIGV QLKDIKVFNR DRQKGTNVCA VANGGCQQLC LYRGRGQRAC ACAHGMLAED GASCREYAGY LLYSERTILK SIHLSDERNL NAPVQPFEDP EHMKNVIALA FDYRAGTSPG TPNRIFFSDI HFGNIQQIND DGSRRITIVE NVGSVEGLAY HRGWDTLYWT SYTTSTITRH TVDQTRPGAF ERETVITMSG DDHPRAFVLD ECQNLMFWTN WNEQHPSIMR AALSGANVLT LIEKDIRTPN GLAIDHRAEK LYFSDATLDK IERCEYDGSH RYVILKSEPV HPFGLAVYGE HIFWTDWVRR AVQRANKHVG SNMKLLRVDI PQQPMGIIAV ANDTNSCELS PCRINNGGCQ DLCLLTHQGH VNCSCRGGRI LQDDLTCRAV NSSCRAQDEF ECANGECINF SLTCDGVPHC KDKSDEKPSY CNSRRCKKTF RQCSNGRCVS NMLWCNGADD CGDGSDEIPC NKTACGVGEF RCRDGTCIGN SSRCNQFVDC EDASDEMNCS ATDCSSYFRL GVKGVLFQPC ERTSLCYAPS WVCDGANDCG DYSDERDCPG VKRPRCPLNY FACPSGRCIP MSWTCDKEDD CEHGEDETHC NKFCSEAQFE CQNHRCISKQ WLCDGSDDCG DGSDEAAHCE GKTCGPSSFS CPGTHVCVPE RWLCDGDKDC ADGADESIAA GCLYNSTCDD REFMCQNRQC IPKHFVCDHD RDCADGSDES PECEYPTCGP SEFRCANGRC LSSRQWECDG ENDCHDQSDE APKNPHCTSP EHKCNASSQF LCSSGRCVAE ALLCNGQDDC GDSSDERGCH INECLSRKLS GCSQDCEDLK IGFKCRCRPG FRLKDDGRTC ADVDECSTTF PCSQRCINTH GSYKCLCVEG YAPRGGDPHS CKAVTDEEPF LIFANRYYLR KLNLDGSNYT LLKQGLNNAV ALDFDYREQM IYWTDVTTQG SMIRRMHLNG SNVQVLHRTG LSNPDGLAVD WVGGNLYWCD KGRDTIEVSK LNGAYRTVLV SSGLREPRAL VVDVQNGYLY WTDWGDHSLI GRIGMDGSSR SVIVDTKITW PNGLTLDYVT ERIYWADARE DYIEFASLDG SNRHVVLSQD IPHIFALTLF EDYVYWTDWE TKSINRAHKT TGTNKTLLIS TLHRPMDLHV FHALRQPDVP NHPCKVNNGG CSNLCLLSPG GGHKCACPTN FYLGSDGRTC VSNCTASQFV CKNDKCIPFW WKCDTEDDCG DHSDEPPDCP EFKCRPGQFQ CSTGICTNPA FICDGDNDCQ DNSDEANCDI HVCLPSQFKC TNTNRCIPGI FRCNGQDNCG DGEDERDCPE VTCAPNQFQC SITKRCIPRV WVCDRDNDCV DGSDEPANCT QMTCGVDEFR CKDSGRCIPA RWKCDGEDDC GDGSDEPKEE CDERTCEPYQ FRCKNNRCVP GRWQCDYDND CGDNSDEESC TPRPCSESEF SCANGRCIAG RWKCDGDHDC ADGSDEKDCT PRCDMDQFQC KSGHCIPLRW RCDADADCMD GSDEEACGTG VRTCPLDEFQ CNNTLCKPLA WKCDGEDDCG DNSDENPEEC ARFVCPPNRP FRCKNDRVCL WIGRQCDGTD NCGDGTDEED CEPPTAHTTH CKDKKEFLCR NQRCLSSSLR CNMFDDCGDG SDEEDCSIDP KLTSCATNAS ICGDEARCVR TEKAAYCACR SGFHTVPGQP GCQDINECLR FGTCSQLCNN TKGGHLCSCA RNFMKTHNTC KAEGSEYQVL YIADDNEIRS LFPGHPHSAY EQAFQGDESV RIDAMDVHVK AGRVYWTNWH TGTISYRSLP PAAPPTTSNR HRRQIDRGVT HLNISGLKMP RGIAIDWVAG NVYWTDSGRD VIEVAQMKGE NRKTLISGMI DEPHAIVVDP LRGTMYWSDW GNHPKIETAA MDGTLRETLV QDNIQWPTGL AVDYHNERLY WADAKLSVIG SIRLNGTDPI VAADSKRGLS HPFSIDVFED YIYGVTYINN RVFKIHKFGH SPLVNLTGGL SHASDVVLYH QHKQPEVTNP CDRKKCEWLC LLSPSGPVCT CPNGKRLDNG TCVPVPSPTP PPDAPRPGTC NLQCFNGGSC FLNARRQPKC RCQPRYTGDK CELDQCWEHC RNGGTCAASP SGMPTCRCPT GFTGPKCTQQ VCAGYCANNS TCTVNQGNQP QCRCLPGFLG DRCQYRQCSG YCENFGTCQM AADGSRQCRC TAYFEGSRCE VNKCSRCLEG ACVVNKQSGD VTCNCTDGRV APSCLTCVGH CSNGGSCTMN SKMMPECQCP PHMTGPRCEE HVFSQQQPGH IASILIPLLL LLLLVLVAGV VFWYKRRVQG AKGFQHQRMT NGAMNVEIGN PTYKMYEGGE PDDVGGLLDA DFALDPDKPT NFTNPVYATL YMGGHGSRHS LASTDEKREL LGRGPEDEIG DPLA