LRP1B_HUMAN » Low-density lipoprotein receptor-related protein 1B

LRP1B_HUMAN » Low-density lipoprotein receptor-related protein 1B
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRP1B_HUMAN » Low-density lipoprotein receptor-related protein 1B » LRP-1B; Low-density lipoprotein receptor-related protein-deleted in tumor;LRP-DIT;
Hydrophobic Thickness 35.2 ± 5.2 Å
Tilt Angle 22 ± 17°
ΔGtransfer -30.3 kcal/mol
ΔGfold -24.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 4443-4468 (4437-4471)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: A4:LRP1B, PubMed

Domains

AA: 30-69, PDBID: 1F5Y, Subunit A, Seq Identity:48%, Low-density lipoprotein receptor domain class A

AA: 75-113, PDBID: 2JM4, Subunit A, Seq Identity:41%, Low-density lipoprotein receptor domain class A

AA: 155-193, PDBID: 1UZJ, Subunit B, Seq Identity:44%, Calcium-binding EGF domain

AA: 295-335, PDBID: 3S94, Subunit B, Seq Identity:48%, Low-density lipoprotein receptor repeat class B

AA: 568-608, PDBID: 3S2K, Subunit A, Seq Identity:41%, Low-density lipoprotein receptor repeat class B

AA: 611-654, PDBID: 3S94, Subunit B, Seq Identity:44%, Low-density lipoprotein receptor repeat class B

AA: 657-704, PDBID: 3S94, Subunit B, Seq Identity:48%, Low-density lipoprotein receptor repeat class B

AA: 798-833, PDBID: 3S94, Subunit A, Seq Identity:51%, Coagulation Factor Xa inhibitory site

AA: 843-881, PDBID: 1D2L, Subunit A, Seq Identity:56%, Low-density lipoprotein receptor domain class A

AA: 884-922, PDBID: 1J8E, Subunit A, Seq Identity:58%, Low-density lipoprotein receptor domain class A

AA: 925-962, PDBID: 2FYJ, Subunit A, Seq Identity:66%, Low-density lipoprotein receptor domain class A

AA: 965-1002, PDBID: 2FYJ, Subunit A, Seq Identity:70%, Low-density lipoprotein receptor domain class A

AA: 1004-1042, PDBID: 1J8E, Subunit A, Seq Identity:73%, Low-density lipoprotein receptor domain class A

AA: 1051-1088, PDBID: 1CR8, Subunit A, Seq Identity:57%, Low-density lipoprotein receptor domain class A

AA: 1093-1131, PDBID: 3OJY, Subunit A, Seq Identity:52%, Low-density lipoprotein receptor domain class A

AA: 1176-1212, PDBID: 3S2K, Subunit A, Seq Identity:51%, Coagulation Factor Xa inhibitory site

AA: 1347-1387, PDBID: 3S94, Subunit B, Seq Identity:55%, Low-density lipoprotein receptor repeat class B

AA: 1390-1434, PDBID: 3V64, Subunit D, Seq Identity:45%, Low-density lipoprotein receptor repeat class B

AA: 1618-1658, PDBID: 3S2K, Subunit A, Seq Identity:53%, Low-density lipoprotein receptor repeat class B

AA: 1838-1874, PDBID: 1AUT, Subunit L, Seq Identity:42%, Coagulation Factor Xa inhibitory site

AA: 1965-2005, PDBID: 3S94, Subunit B, Seq Identity:55%, Low-density lipoprotein receptor repeat class B

AA: 2008-2049, PDBID: 3S94, Subunit B, Seq Identity:53%, Low-density lipoprotein receptor repeat class B

AA: 2330-2372, PDBID: 3S94, Subunit B, Seq Identity:45%, Low-density lipoprotein receptor repeat class B

AA: 2508-2547, PDBID: 1AJJ, Subunit A, Seq Identity:50%, Low-density lipoprotein receptor domain class A

AA: 2550-2586, PDBID: 3T5O, Subunit A, Seq Identity:53%, Low-density lipoprotein receptor domain class A

AA: 2589-2625, PDBID: 1N7D, Subunit A, Seq Identity:52%, Low-density lipoprotein receptor domain class A

AA: 2641-2674, PDBID: 2XRC, Subunit D, Seq Identity:50%, Low-density lipoprotein receptor domain class A

AA: 2680-2716, PDBID: 1J8E, Subunit A, Seq Identity:51%, Low-density lipoprotein receptor domain class A

AA: 2718-2756, PDBID: 1J8E, Subunit A, Seq Identity:46%, Low-density lipoprotein receptor domain class A

AA: 2759-2799, PDBID: 2KNX, Subunit A, Seq Identity:55%, Low-density lipoprotein receptor domain class A

AA: 2803-2840, PDBID: 2KNY, Subunit A, Seq Identity:71%, Low-density lipoprotein receptor domain class A

AA: 2843-2884, PDBID: 1D2L, Subunit A, Seq Identity:47%, Low-density lipoprotein receptor domain class A

AA: 2889-2925, PDBID: 1J8E, Subunit A, Seq Identity:56%, Low-density lipoprotein receptor domain class A

AA: 2948-2971, PDBID: 1HJ7, Subunit A, Seq Identity:52%, Complement Clr-like EGF-like

AA: 3007-3241, PDBID: 3S25, Subunit A, Seq Identity:7%, Domain of unknown function (DUF5050)

AA: 3277-3313, PDBID: 3S94, Subunit A, Seq Identity:55%, Coagulation Factor Xa inhibitory site

AA: 3315-3352, PDBID: 3A7Q, Subunit B, Seq Identity:52%, Low-density lipoprotein receptor domain class A

AA: 3355-3391, PDBID: 2M96, Subunit A, Seq Identity:52%, Low-density lipoprotein receptor domain class A

AA: 3394-3431, PDBID: 2JM4, Subunit A, Seq Identity:51%, Low-density lipoprotein receptor domain class A

AA: 3434-3471, PDBID: 1N7D, Subunit A, Seq Identity:55%, Low-density lipoprotein receptor domain class A

AA: 3474-3510, PDBID: 3A7Q, Subunit B, Seq Identity:55%, Low-density lipoprotein receptor domain class A

AA: 3513-3549, PDBID: 1N7D, Subunit A, Seq Identity:52%, Low-density lipoprotein receptor domain class A

AA: 3551-3587, PDBID: 1J8E, Subunit A, Seq Identity:51%, Low-density lipoprotein receptor domain class A

AA: 3592-3628, PDBID: 3T5O, Subunit A, Seq Identity:51%, Low-density lipoprotein receptor domain class A

AA: 3630-3667, PDBID: 1CR8, Subunit A, Seq Identity:51%, Low-density lipoprotein receptor domain class A

AA: 3672-3710, PDBID: 1D2L, Subunit A, Seq Identity:56%, Low-density lipoprotein receptor domain class A

AA: 3760-3796, PDBID: 1D2J, Subunit A, Seq Identity:56%, Low-density lipoprotein receptor domain class A

AA: 3844-3880, PDBID: 1EMN, Subunit A, Seq Identity:42%, Calcium-binding EGF domain

AA: 4039-4080, PDBID: 3S94, Subunit B, Seq Identity:50%, Low-density lipoprotein receptor repeat class B

AA: 4253-4283, PDBID: 1APO, Subunit A, Seq Identity:45%, EGF-like domain

UniProt annotation for LRP1B_HUMAN » Low-density lipoprotein receptor-related protein 1B
FUNCTION: Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.

SUBUNIT: Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the ligands.

TISSUE SPECIFICITY: Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain.

MISCELLANEOUS: The gene is preferentially inactivated in one histological type of lung cancer (non-small cell lung cancer (NSCLC)). May thus play an important role in tumorigenesis of NSCLCs.

Amino Acid Sequence for LRP1B_HUMAN » Low-density lipoprotein receptor-related protein 1B
MSEFLLALLT LSGLLPIARV LTVGADRDQQ LCDPGEFLCH DHVTCVSQSW LCDGDPDCPD DSDESLDTCP EEVEIKCPLN HIACLGTNKC VHLSQLCNGV LDCPDGYDEG VHCQELLSNC QQLNCQYKCT MVRNSTRCYC EDGFEITEDG RSCKDQDECA VYGTCSQTCR NTHGSYTCSC VEGYLMQPDN RSCKAKIEPT DRPPILLIAN FETIEVFYLN GSKMATLSSV NGNEIHTLDF IYNEDMICWI ESRESSNQLK CIQITKAGGL TDEWTINILQ SFHNVQQMAI DWLTRNLYFV DHVGDRIFVC NSNGSVCVTL IDLELHNPKA IAVDPIAGKL FFTDYGNVAK VERCDMDGMN RTRIIDSKTE QPAALALDLV NKLVYWVDLY LDYVGVVDYQ GKNRHTVIQG RQVRHLYGIT VFEDYLYATN SDNYNIVRIN RFNGTDIHSL IKIENAWGIR IYQKRTQPTV RSHACEVDPY GMPGGCSHIC LLSSSYKTRT CRCRTGFNLG SDGRSCKRPK NELFLFYGKG RPGIVRGMDL NTKIADEYMI PIENLVNPRA LDFHAETNYI YFADTTSFLI GRQKIDGTER ETILKDDLDN VEGIAVDWIG NNLYWTNDGH RKTINVARLE KASQSRKTLL EGEMSHPRGI VVDPVNGWMY WTDWEEDEID DSVGRIEKAW MDGFNRQIFV TSKMLWPNGL TLDFHTNTLY WCDAYYDHIE KVFLNGTHRK IVYSGRELNH PFGLSHHGNY VFWTDYMNGS IFQLDLITSE VTLLRHERPP LFGLQIYDPR KQQGDNMCRV NNGGCSTLCL AIPGGRVCAC ADNQLLDENG TTCTFNPGEA LPHICKAGEF RCKNRHCIQA RWKCDGDDDC LDGSDEDSVN CFNHSCPDDQ FKCQNNRCIP KRWLCDGAND CGSNEDESNQ TCTARTCQVD QFSCGNGRCI PRAWLCDRED DCGDQTDEMA SCEFPTCEPL TQFVCKSGRC ISSKWHCDSD DDCGDGSDEV GCVHSCFDNQ FRCSSGRCIP GHWACDGDND CGDFSDEAQI NCTKEEIHSP AGCNGNEFQC HPDGNCVPDL WRCDGEKDCE DGSDEKGCNG TIRLCDHKTK FSCWSTGRCI NKAWVCDGDI DCEDQSDEDD CDSFLCGPPK HPCANDTSVC LQPEKLCNGK KDCPDGSDEG YLCDECSLNN GGCSNHCSVV PGRGIVCSCP EGLQLNKDNK TCEIVDYCSN HLKCSQVCEQ HKHTVKCSCY EGWKLDVDGE SCTSVDPFEA FIIFSIRHEI RRIDLHKRDY SLLVPGLRNT IALDFHFNQS LLYWTDVVED RIYRGKLSES GGVSAIEVVV EHGLATPEGL TVDWIAGNIY WIDSNLDQIE VAKLDGSLRT TLIAGAMEHP RAIALDPRYG ILFWTDWDAN FPRIESASMS GAGRKTIYKD MKTGAWPNGL TVDHFEKRIV WTDARSDAIY SALYDGTNMI EIIRGHEYLS HPFAVSLYGS EVYWTDWRTN TLSKANKWTG QNVSVIQKTS AQPFDLQIYH PSRQPQAPNP CAANDGKGPC SHMCLINHNR SAACACPHLM KLSSDKKTCY EMKKFLLYAR RSEIRGVDID NPYFNFITAF TVPDIDDVTV IDFDASEERL YWTDIKTQTI KRAFINGTGL ETVISRDIQS IRGLAVDWVS RNLYWISSEF DETQINVARL DGSLKTSIIH GIDKPQCLAA HPVRGKLYWT DGNTINMANM DGSNSKILFQ NQKEPVGLSI DYVENKLYWI SSGNGTINRC NLDGGNLEVI ESMKEELTKA TALTIMDKKL WWADQNLAQL GTCSKRDGRN PTILRNKTSG VVHMKVYDKE AQQGSNSCQL NNGGCSQLCL PTSETTRTCM CTVGYYLQKN RMSCQGIESF LMYSVHEGIR GIPLEPSDKM DALMPISGTS FAVGIDFHAE NDTIYWTDMG FNKISRAKRD QTWKEDIITN GLGRVEGIAV DWIAGNIYWT DHGFNLIEVA RLNGSFRYVI ISQGLDQPRS IAVHPEKGLL FWTEWGQMPC IGKARLDGSE KVVLVSMGIA WPNGISIDYE ENKLYWCDAR TDKIERIDLE TGGNREMVLS GSNVDMFSVA VFGAYIYWSD RAHANGSVRR GHKNDATETI TMRTGLGVNL KEVKIFNRVR EKGTNVCARD NGGCKQLCLY RGNSRRTCAC AHGYLAEDGV TCLRHEGYLL YSGRTILKSI HLSDETNLNS PIRPYENPRY FKNVIALAFD YNQRRKGTNR IFYSDAHFGN IQLIKDNWED RQVIVENVGS VEGLAYHRAW DTLYWTSSTT SSITRHTVDQ TRPGAFDREA VITMSEDDHP HVLALDECQN LMFWTNWNEQ HPSIMRSTLT GKNAQVVVST DILTPNGLTI DYRAEKLYFS DGSLGKIERC EYDGSQRHVI VKSGPGTFLS LAVYDNYIFW SDWGRRAILR SNKYTGGDTK ILRSDIPHQP MGIIAVANDT NSCELSPCAL LNGGCHDLCL LTPNGRVNCS CRGDRILLED NRCVTKNSSC NAYSEFECGN GECIDYQLTC DGIPHCKDKS DEKLLYCENR SCRRGFKPCY NRRCIPHGKL CDGENDCGDN SDELDCKVST CATVEFRCAD GTCIPRSARC NQNIDCADAS DEKNCNNTDC THFYKLGVKT TGFIRCNSTS LCVLPTWICD GSNDCGDYSD ELKCPVQNKH KCEENYFSCP SGRCILNTWI CDGQKDCEDG RDEFHCDSSC SWNQFACSAQ KCISKHWICD GEDDCGDGLD ESDSICGAIT CAADMFSCQG SRACVPRHWL CDGERDCPDG SDELSTAGCA PNNTCDENAF MCHNKVCIPK QFVCDHDDDC GDGSDESPQC GYRQCGTEEF SCADGRCLLN TQWQCDGDFD CPDHSDEAPL NPKCKSAEQS CNSSFFMCKN GRCIPSGGLC DNKDDCGDGS DERNCHINEC LSKKVSGCSQ DCQDLPVSYK CKCWPGFQLK DDGKTCVDID ECSSGFPCSQ QCINTYGTYK CLCTDGYEIQ PDNPNGCKSL SDEEPFLILA DHHEIRKIST DGSNYTLLKQ GLNNVIAIDF DYREEFIYWI DSSRPNGSRI NRMCLNGSDI KVVHNTAVPN ALAVDWIGKN LYWSDTEKRI IEVSKLNGLY PTILVSKRLK FPRDLSLDPQ AGYLYWIDCC EYPHIGRVGM DGTNQSVVIE TKISRPMALT IDYVNRRLYW ADENHIEFSN MDGSHRHKVP NQDIPGVIAL TLFEDYIYWT DGKTKSLSRA HKTSGADRLS LIYSWHAITD IQVYHSYRQP DVSKHLCMIN NGGCSHLCLL APGKTHTCAC PTNFYLAADN RTCLSNCTAS QFRCKTDKCI PFWWKCDTVD DCGDGSDEPD DCPEFRCQPG RFQCGTGLCA LPAFICDGEN DCGDNSDELN CDTHVCLSGQ FKCTKNQKCI PVNLRCNGQD DCGDEEDERD CPENSCSPDY FQCKTTKHCI SKLWVCDEDP DCADASDEAN CDKKTCGPHE FQCKNNNCIP DHWRCDSQND CSDNSDEENC KPQTCTLKDF LCANGDCVSS RFWCDGDFDC ADGSDERNCE TSCSKDQFRC SNGQCIPAKW KCDGHEDCKY GEDEKSCEPA SPTCSSREYI CASDGCISAS LKCNGEYDCA DGSDEMDCVT ECKEDQFRCK NKAHCIPIRW LCDGIHDCVD GSDEENCERG GNICRADEFL CNNSLCKLHF WVCDGEDDCG DNSDEAPDMC VKFLCPSTRP HRCRNNRICL QSEQMCNGID ECGDNSDEDH CGGKLTYKAR PCKKDEFACS NKKCIPMDLQ CDRLDDCGDG SDEQGCRIAP TEYTCEDNVN PCGDDAYCNQ IKTSVFCRCK PGFQRNMKNR QCEDLNECLV FGTCSHQCIN VEGSYKCVCD QNFQERNNTC IAEGSEDQVL YIANDTDILG FIYPFNYSGD HQQISHIEHN SRITGMDVYY QRDMIIWSTQ FNPGGIFYKR IHGREKRQAN SGLICPEFKR PRDIAVDWVA GNIYWTDHSR MHWFSYYTTH WTSLRYSINV GQLNGPNCTR LLTNMAGEPY AIAVNPKRGM MYWTVVGDHS HIEEAAMDGT LRRILVQKNL QRPTGLAVDY FSERIYWADF ELSIIGSVLY DGSNSVVSVS SKQGLLHPHR IDIFEDYIYG AGPKNGVFRV QKFGHGSVEY LALNIDKTKG VLISHRYKQL DLPNPCLDLA CEFLCLLNPS GATCVCPEGK YLINGTCNDD SLLDDSCKLT CENGGRCILN EKGDLRCHCW PSYSGERCEV NHCSNYCQNG GTCVPSVLGR PTCSCALGFT GPNCGKTVCE DFCQNGGTCI VTAGNQPYCH CQPEYTGDRC QYYVCHHYCV NSESCTIGDD GSVECVCPTR YEGPKCEVDK CVRCHGGHCI INKDSEDIFC NCTNGKIASS CQLCDGYCYN GGTCQLDPET NVPVCLCSTN WSGTQCERPA PKSSKSDHIS TRSIAIIVPL VLLVTLITTL VIGLVLCKRK RRTKTIRRQP IINGGINVEI GNPSYNMYEV DHDHNDGGLL DPGFMIDPTK ARYIGGGPSA FKLPHTAPPI YLNSDLKGPL TAGPTNYSNP VYAKLYMDGQ NCRNSLGSVD ERKELLPKKI EIGIRETVA