LRP12_HUMAN » Low-density lipoprotein receptor-related protein 12

LRP12_HUMAN » Low-density lipoprotein receptor-related protein 12
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRP12_HUMAN » Low-density lipoprotein receptor-related protein 12 » LRP-12; Suppressor of tumorigenicity 7 protein;
Hydrophobic Thickness 36.0 ± 4.0 Å
Tilt Angle 40 ± 6°
ΔGtransfer -22.2 kcal/mol
ΔGfold -18.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 490-518 (490-522)
Pathways

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 47-156, PDBID: 1NT0, Subunit A, Seq Identity:33%, CUB domain

AA: 164-200, PDBID: 2FYJ, Subunit A, Seq Identity:52%, Low-density lipoprotein receptor domain class A

AA: 213-254, PDBID: 1AJJ, Subunit A, Seq Identity:43%, Low-density lipoprotein receptor domain class A

AA: 259-369, PDBID: 3KQ4, Subunit B, Seq Identity:37%, CUB domain

AA: 411-448, PDBID: 2M96, Subunit A, Seq Identity:47%, Low-density lipoprotein receptor domain class A

AA: 450-485, PDBID: 2M96, Subunit A, Seq Identity:52%, Low-density lipoprotein receptor domain class A

UniProt annotation for LRP12_HUMAN » Low-density lipoprotein receptor-related protein 12
FUNCTION: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.

SUBUNIT: May interact with GNB2L1, ZFYVE9 and NMRK2.

TISSUE SPECIFICITY: Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.

UniProt features for LRP12_HUMAN » Low-density lipoprotein receptor-related protein 12
SIGNAL 1 32 Potential.
CHAIN 33 859 Low-density lipoprotein receptor-related protein 12.
DOMAIN 47 159 CUB 1.
DOMAIN 165 201 LDL-receptor class A 1.
DOMAIN 214 255 LDL-receptor class A 2.
DOMAIN 259 372 CUB 2.
DOMAIN 374 411 LDL-receptor class A 3.
DOMAIN 412 449 LDL-receptor class A 4.
DOMAIN 450 486 LDL-receptor class A 5.
DISULFID 47 76 By similarity.
DISULFID 103 122 By similarity.
DISULFID 166 178 By similarity.
DISULFID 173 191 By similarity.
DISULFID 185 200 By similarity.
DISULFID 215 232 By similarity.
DISULFID 222 245 By similarity.
DISULFID 239 254 By similarity.
DISULFID 259 285 By similarity.
DISULFID 375 388 By similarity.
DISULFID 382 401 By similarity.
DISULFID 395 410 By similarity.
DISULFID 413 426 By similarity.
DISULFID 420 439 By similarity.
DISULFID 433 448 By similarity.
DISULFID 451 463 By similarity.
DISULFID 458 476 By similarity.
DISULFID 470 485 By similarity.
Amino Acid Sequence for LRP12_HUMAN » Low-density lipoprotein receptor-related protein 12
MACRWSTKES PRWRSALLLL FLAGVYGNGA LAEHSENVHI SGVSTACGET PEQIRAPSGI ITSPGWPSEY PAKINCSWFI RANPGEIITI SFQDFDIQGS RRCNLDWLTI ETYKNIESYR ACGSTIPPPY ISSQDHIWIR FHSDDNISRK GFRLAYFSGK SEEPNCACDQ FRCGNGKCIP EAWKCNNMDE CGDSSDEEIC AKEANPPTAA AFQPCAYNQF QCLSRFTKVY TCLPESLKCD GNIDCLDLGD EIDCDVPTCG QWLKYFYGTF NSPNYPDFYP PGSNCTWLID TGDHRKVILR FTDFKLDGTG YGDYVKIYDG LEENPHKLLR VLTAFDSHAP LTVVSSSGQI RVHFCADKVN AARGFNATYQ VDGFCLPWEI PCGGNWGCYT EQQRCDGYWH CPNGRDETNC TMCQKEEFPC SRNGVCYPRS DRCNYQNHCP NGSDEKNCFF CQPGNFHCKN NRCVFESWVC DSQDDCGDGS DEENCPVIVP TRVITAAVIG SLICGLLLVI ALGCTCKLYS LRMFERRSFE TQLSRVEAEL LRREAPPSYG QLIAQGLIPP VEDFPVCSPN QASVLENLRL AVRSQLGFTS VRLPMAGRSS NIWNRIFNFA RSRHSGSLAL VSADGDEVVP SQSTSREPER NHTHRSLFSV ESDDTDTENE RRDMAGASGG VAAPLPQKVP PTTAVEATVG ACASSSTQST RGGHADNGRD VTSVEPPSVS PARHQLTSAL SRMTQGLRWV RFTLGRSSSL SQNQSPLRQL DNGVSGREDD DDVEMLIPIS DGSSDFDVND CSRPLLDLAS DQGQGLRQPY NATNPGVRPS NRDGPCERCG IVHTAQIPDT CLEVTLKNET SDDEALLLC