LRP10_HUMAN » Low-density lipoprotein receptor-related protein 10

LRP10_HUMAN » Low-density lipoprotein receptor-related protein 10
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRP10_HUMAN » Low-density lipoprotein receptor-related protein 10 » LRP-10;
Hydrophobic Thickness 38.4 ± 6.6 Å
Tilt Angle 35 ± 6°
ΔGtransfer -22.3 kcal/mol
ΔGfold -18.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 436-465 (436-470)
Pathways

Signal Transduction (Reactome)
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 138-174, PDBID: 2FYJ, Subunit A, Seq Identity:48%, Low-density lipoprotein receptor domain class A

AA: 192-302, PDBID: 3KQ4, Subunit B, Seq Identity:29%, CUB domain

AA: 397-433, PDBID: 1F5Y, Subunit A, Seq Identity:48%, Low-density lipoprotein receptor domain class A
UniProt annotation for LRP10_HUMAN » Low-density lipoprotein receptor-related protein 10
FUNCTION: Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).

TISSUE SPECIFICITY: Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle and heart.

UniProt features for LRP10_HUMAN » Low-density lipoprotein receptor-related protein 10
SIGNAL 1 16 Potential.
CHAIN 17 713 Low-density lipoprotein receptor-related protein 10.
DOMAIN 28 136 CUB 1.
DOMAIN 139 175 LDL-receptor class A 1.
DOMAIN 192 305 CUB 2.
DOMAIN 307 354 LDL-receptor class A 2.
DOMAIN 355 397 LDL-receptor class A 3.
DOMAIN 398 434 LDL-receptor class A 4.
DISULFID 28 57 By similarity.
DISULFID 80 98 By similarity.
DISULFID 140 152 By similarity.
DISULFID 147 165 By similarity.
DISULFID 159 174 By similarity.
DISULFID 192 220 By similarity.
DISULFID 308 331 By similarity.
DISULFID 315 344 By similarity.
DISULFID 338 353 By similarity.
DISULFID 356 374 By similarity.
DISULFID 363 387 By similarity.
DISULFID 381 396 By similarity.
DISULFID 399 411 By similarity.
DISULFID 406 424 By similarity.
DISULFID 418 433 By similarity.
Amino Acid Sequence for LRP10_HUMAN » Low-density lipoprotein receptor-related protein 10
MLLATLLLLL LGGALAHPDR IIFPNHACED PPAVLLEVQG TLQRPLVRDS RTSPANCTWL ILGSKEQTVT IRFQKLHLAC GSERLTLRSP LQPLISLCEA PPSPLQLPGG NVTITYSYAG ARAPMGQGFL LSYSQDWLMC LQEEFQCLNH RCVSAVQRCD GVDACGDGSD EAGCSSDPFP GLTPRPVPSL PCNVTLEDFY GVFSSPGYTH LASVSHPQSC HWLLDPHDGR RLAVRFTALD LGFGDAVHVY DGPGPPESSR LLRSLTHFSN GKAVTVETLS GQAVVSYHTV AWSNGRGFNA TYHVRGYCLP WDRPCGLGSG LGAGEGLGER CYSEAQRCDG SWDCADGTDE EDCPGCPPGH FPCGAAGTSG ATACYLPADR CNYQTFCADG ADERRCRHCQ PGNFRCRDEK CVYETWVCDG QPDCADGSDE WDCSYVLPRK VITAAVIGSL VCGLLLVIAL GCTCKLYAIR TQEYSIFAPL SRMEAEIVQQ QAPPSYGQLI AQGAIPPVED FPTENPNDNS VLGNLRSLLQ ILRQDMTPGG GPGARRRQRG RLMRRLVRRL RRWGLLPRTN TPARASEARS QVTPSAAPLE ALDGGTGPAR EGGAVGGQDG EQAPPLPIKA PLPSASTSPA PTTVPEAPGP LPSLPLEPSL LSGVVQALRG RLLPSLGPPG PTRSPPGPHT AVLALEDEDD VLLVPLAEPG VWVAEAEDEP LLT