LRMP_HUMAN » Lymphoid-restricted membrane protein

LRMP_HUMAN » Lymphoid-restricted membrane protein
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
LRMP_HUMAN » Lymphoid-restricted membrane protein » Protein Jaw1;
Hydrophobic Thickness 30.8 ± 3.2 Å
Tilt Angle 2 ± 11°
ΔGtransfer -22.8 kcal/mol
ΔGfold -20.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 495-515 (489-526)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 23-555, MRVI1 protein

UniProt annotation for LRMP_HUMAN » Lymphoid-restricted membrane protein
FUNCTION: Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion.

SUBUNIT: Interacts (via coiled-coil domain) with ITPR3.

TISSUE SPECIFICITY: Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles.

UniProt features for LRMP_HUMAN » Lymphoid-restricted membrane protein
CHAIN 1 555 Lymphoid-restricted membrane protein.
CHAIN 1 ? Processed lymphoid-restricted membrane protein.
COILED 227 341 Potential.
Amino Acid Sequence for LRMP_HUMAN » Lymphoid-restricted membrane protein
MESTPFSGVA NQIHTLCERP TYGEVKDGAL DVKRQHKCPG PTSGPSPGTN LSGCIRMNDD PSMEENGVER VCPESLLQSR EYSSLPLPRH TSSTDGTITS SDPGLEILNM ASCDLDRNSL CKKEEDTRSA SPTIEAQGTS PAHDNIAFQD STSKDKTILN LEAKEEPETI EEHKKEHASG DSVVSPLPVT TVKSVNVRQS ENTSANEKEV EAEFLRLSLG FKCDWFTLEK RVKLEERSRD LAEENLKKEI TNCLKLLESL TPLCEDDNQA QEIIKKLEKS IKFLSQCAAR VASRAEMLGA INQESRVSKA VEVMIQHVEN LKRMYAKEHA ELEELKQVLL QNERSFNPLE DDDDCQIKKR SASLNSKPSS LRRVTIASLP RNIGNAGMVA GMENNDRFSR RSSSWRILGS KQSEHRPSLP RFISTYSWAD AEEEKCELKT KDDSEPSGEE TVERTRKPSL SEKKNNPSKW DVSSVYDTIA SWATNLKSSI RKANKALWLS IAFIVLFAAL MSFLTGQLFQ KSVDAAPTQQ EDSWTSLEHI LWPFTRLRHN GPPPV