LRIT3_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3

LRIT3_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
LRIT3_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 »
Hydrophobic Thickness 36.0 ± 7.2 Å
Tilt Angle 30 ± 22°
ΔGtransfer -25.8 kcal/mol
ΔGfold -18.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 454-480 (450-482)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 59-117, PDBID: 3WPE, Subunit A, Seq Identity:35%, Leucine rich repeat

AA: 129-181, PDBID: 4B8C, Subunit L, Seq Identity:44%, Leucine rich repeat

AA: 253-332, PDBID: 5EO9, Subunit B, Seq Identity:29%, Immunoglobulin domain

UniProt annotation for LRIT3_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3
FUNCTION: Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi. Could be a regulator of the FGFRs.

DISEASE: Night blindness, congenital stationary, 1F (CSNB1F) OMIM: An autosomal recessive form of congenital stationary night blindness, a non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. by mutations affecting the gene represented in this entry.

UniProt features for LRIT3_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3
SIGNAL 1 19 Potential.
CHAIN 20 679 Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain- containing protein 3.
REPEAT 56 79 LRR 1.
REPEAT 80 103 LRR 2.
REPEAT 104 128 LRR 3.
REPEAT 129 151 LRR 4.
REPEAT 152 175 LRR 5.
DOMAIN 201 253 LRRCT.
DOMAIN 254 344 Ig-like.
DOMAIN 484 574 Fibronectin type-III.
DISULFID 275 328 By similarity.
Amino Acid Sequence for LRIT3_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3
MPLLRTLDLH NNKITSVPNE ALRYLKNLAY LDLSSNRLTT LTPDFLENWT HLVSTPSGVL DLSPSRIILG LQDNPWFCDC HISKMIELSK VVDPAIVLLD PLMTCSEPER LTGILFQRAE LEHCLKPSVM TSATKIMSAL GSNVLLRCDA TGFPTPQITW TRSDSSPVNY TVIQESPEEG VRWSIMSLTG ISSKDAGDYK CKAKNLAGMS EAVVTVTVLG ITTTPIPPDT SERTGDHPEW DVQPGSGRST SVSSASSYLW SSSFSPTSSF SASTLSPPST ASFSLSPFSS STVSSTTTLS TSISASTTMA NKRSFQLHQG GKRNLKVAKN GSKLPPASTS KKEELALLDQ TMLTETNATI ENLRVVSETK ESVTLMWNMI NTTHNSAVTV LYSKYGGKDL LLLNADSSKN QVTIDGLEPG GQYMACVCPK GVPPQKDQCI TFSTERVEGD DSQWSLLLVV TSTACVVILP LICFLLYKVC KLQCKSEPFW EDDLAKETYI QFETLFPRSQ SVGELWTRSH RDDSEKLLLC SRSSVESQVT FKSEGSRPEY YC