LRIT2_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2

LRIT2_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRIT2_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 » Leucine-rich repeat-containing protein 22;
Hydrophobic Thickness 33.0 ± 2.0 Å
Tilt Angle 14 ± 0°
ΔGtransfer -20.2 kcal/mol
ΔGfold -14.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 463-485 (459-487)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 56-115, PDBID: 1XCD, Subunit A, Seq Identity:39%, Leucine rich repeat

AA: 113-163, PDBID: 4Y61, Subunit B, Seq Identity:46%, Leucine rich repeat

AA: 252-331, PDBID: 2OM5, Subunit A, Seq Identity:33%, Immunoglobulin domain

UniProt features for LRIT2_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2
SIGNAL 1 19 Potential.
CHAIN 20 550 Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain- containing protein 2.
DOMAIN 23 54 LRRNT.
REPEAT 80 103 LRR 1.
REPEAT 104 125 LRR 2.
REPEAT 128 149 LRR 3.
REPEAT 152 173 LRR 4.
DOMAIN 200 252 LRRCT.
DOMAIN 253 341 Ig-like.
DOMAIN 361 451 Fibronectin type-III.
DISULFID 274 327 By similarity.
Amino Acid Sequence for LRIT2_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2
MASVFHYFLL VLVFLDTHAA QPFCLPGCTC SEESFGRTLQ CTSVSLGKIP GNLSEEFKQV RIENSPLFEM PQGSFINMST LEYLWLNFNN ISVIHLGALE HLPELRELRL EGNKLCSVPW TAFRATPLLR VLDLKRNKID ALPELALQFL VSLTYLDLSS NRLTVVSKSV FLNWPAYQKC RQPDCGAEIL SSLVVALHDN PWVCDCRLRG LVQFVKSITL PVILVNSYLI CQGPLSKAGQ LFHETELSAC MKPQISTPSA NITIRAGQNV TLRCLAQASP SPSIAWTYPL SMWREFDVLT SSTGEDTALS ELAIPAAHLV DSGNYTCMAS NSIGKSNLVI SLHVQPAQAL HAPDSLSIPS EGNAYIDLRV VKQTVHGILL EWLAVADTSK EEWFTLYIAS DEAFRKEVVH IGPGINTYAV DDLLPGTKYE ACLSLEGQPP HQGQCVAFVT GRDAGGLEAR EHLLHVTVVL CVVLLAVPVG AYAWAAQGPC SCSKWVLRGC LHRRKAPSCT PAAPQSKDGS FREHPAVCDD GEGHIDTEGD KEKGGTEDNS