LRIT1_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1

LRIT1_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
LRIT1_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 » Leucine-rich repeat-containing protein 21;Photoreceptor-associated LRR superfamily protein;Retina-specific protein PAL;
Hydrophobic Thickness 31.6 ± 4.8 Å
Tilt Angle 33 ± 0°
ΔGtransfer -22.9 kcal/mol
ΔGfold -21.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 524-549 (521-557)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 122-183, PDBID: 4CNC, Subunit B, Seq Identity:39%, Leucine rich repeat

AA: 256-345, PDBID: 1DJS, Subunit A, Seq Identity:32%, Immunoglobulin I-set domain

AA: 430-502, PDBID: 1TDQ, Subunit A, Seq Identity:29%, Fibronectin type III domain

UniProt annotation for LRIT1_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1
FUNCTION: Possible role in phototransduction.

SUBUNIT: Homodimer.

UniProt features for LRIT1_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1
SIGNAL 1 21 Potential.
CHAIN 22 623 Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain- containing protein 1.
DOMAIN 22 59 LRRNT.
REPEAT 60 81 LRR 1.
REPEAT 84 105 LRR 2.
REPEAT 108 129 LRR 3.
REPEAT 132 153 LRR 4.
REPEAT 156 177 LRR 5.
DOMAIN 201 253 LRRCT.
DOMAIN 266 335 Ig-like C2-type.
DOMAIN 427 519 Fibronectin type-III.
REPEAT 571 594 LRR 6.
DISULFID 275 328 Potential.
Amino Acid Sequence for LRIT1_HUMAN » Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1
MRVALGMLWL LALAWPPQAR GFCPSQCSCS LHIMGDGSKA RTVVCNDPDM TLPPASIPPD TSRLRLERTA IRRVPGEAFR PLGRLEQLWL PYNALSELNA LMLRGLRRLR ELRLPGNRLA AFPWAALRDA PKLRLLDLQA NRLSAVPAEA ARFLENLTFL DLSSNQLMRL PQELIVSWAH LETGIFPPGH HPRRVLGLQD NPWACDCRLY DLVHLLDGWA PNLAFIETEL RCASPRSLAG VAFSQLELRK CQGPELHPGV ASIRSLLGGT ALLRCGATGV PGPEMSWRRA NGRPLNGTVH QEVSSDGTSW TLLGLPAVSH LDSGDYICQA KNFLGASETV ISLIVTEPPT STEHSGSPGA LWARTGGGGE AAAYNNKLVA RHVPQIPKPA VLATGPSVPS TKEELTLEHF QMDALGELSD GRAGPSEARM VRSVKVVGDT YHSVSLVWKA PQAKNTTAFS VLYAVFGQHS MRRVIVQPGK TRVTITGLLP KTKYVACVCV QGLVPRKEQC VIFSTNEVVD AENTQQLINV VVISVAIVIA LPLTLLVCCS ALQKRCRKCF NKDSTEATVT YVNLERLGYS EDGLEELSRH SVSEADRLLS ARSSVDFQAF GVKGGRRINE YFC