LRIG3_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 3

LRIG3_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRIG3_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 3 » LIG-3;
Hydrophobic Thickness 41.2 ± 3.6 Å
Tilt Angle 3 ± 1°
ΔGtransfer -27.4 kcal/mol
ΔGfold -20.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 804-831 (802-835)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 121-179, PDBID: 2Z81, Subunit A, Seq Identity:43%, Leucine rich repeat

AA: 167-227, PDBID: 2ID5, Subunit D, Seq Identity:40%, Leucine rich repeat

AA: 192-251, PDBID: 4U7L, Subunit A, Seq Identity:53%, Leucine rich repeat

AA: 215-275, PDBID: 4KT1, Subunit A, Seq Identity:40%, Leucine rich repeat

AA: 263-323, PDBID: 2XOT, Subunit A, Seq Identity:37%, Leucine rich repeat

AA: 311-371, PDBID: 4U7L, Subunit A, Seq Identity:55%, Leucine rich repeat

AA: 375-446, PDBID: 4U7L, Subunit A, Seq Identity:43%, Leucine rich repeat

AA: 498-585, PDBID: 3SO5, Subunit B, Seq Identity:80%, Immunoglobulin domain

AA: 603-693, PDBID: 4U7M, Subunit A, Seq Identity:88%, Immunoglobulin I-set domain

AA: 697-784, PDBID: 4U7M, Subunit A, Seq Identity:56%, Immunoglobulin I-set domain

UniProt annotation for LRIG3_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 3
FUNCTION: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).

SUBUNIT: Interacts with EGFR, ERBB2 and ERBB4 (in vitro).

TISSUE SPECIFICITY: Widely expressed.

UniProt features for LRIG3_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 3
SIGNAL 1 24 Potential.
CHAIN 25 1119 Leucine-rich repeats and immunoglobulin- like domains protein 3.
DOMAIN 38 74 LRRNT.
REPEAT 75 96 LRR 1.
REPEAT 99 120 LRR 2.
REPEAT 122 142 LRR 3.
REPEAT 146 167 LRR 4.
REPEAT 168 189 LRR 5.
REPEAT 193 214 LRR 6.
REPEAT 216 237 LRR 7.
REPEAT 240 261 LRR 8.
REPEAT 264 285 LRR 9.
REPEAT 288 309 LRR 10.
REPEAT 312 333 LRR 11.
REPEAT 336 357 LRR 12.
REPEAT 360 382 LRR 13.
REPEAT 387 408 LRR 14.
REPEAT 411 432 LRR 15.
DOMAIN 444 495 LRRCT.
DOMAIN 499 598 Ig-like C2-type 1.
DOMAIN 603 692 Ig-like C2-type 2.
DOMAIN 697 783 Ig-like C2-type 3.
DISULFID 520 581 By similarity.
DISULFID 624 676 By similarity.
DISULFID 718 767 By similarity.
Amino Acid Sequence for LRIG3_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 3
MSAPSLRARA AGLGLLLCAV LGRAGRSDSG GRGELGQPSG VAAERPCPTT CRCLGDLLDC SRKRLARLPE PLPSWVARLD LSHNRLSFIK ASSMSHLQSL REVKLNNNEL ETIPNLGPVS ANITLLSLAG NRIVEILPEH LKEFQSLETL DLSSNNISEL QTAFPALQLK YLYLNSNRVT SMEPGYFDNL ANTLLVLKLN RNRISAIPPK MFKLPQLQHL ELNRNKIKNV DGLTFQGLGA LKSLKMQRNG VTKLMDGAFW GLSNMEILQL DHNNLTEITK GWLYGLLMLQ ELHLSQNAIN RISPDAWEFC QKLSELDLTF NHLSRLDDSS FLGLSLLNTL HIGNNRVSYI ADCAFRGLSS LKTLDLKNNE ISWTIEDMNG AFSGLDKLRR LILQGNRIRS ITKKAFTGLD ALEHLDLSDN AIMSLQGNAF SQMKKLQQLH LNTSSLLCDC QLKWLPQWVA ENNFQSFVNA SCAHPQLLKG RSIFAVSPDG FVCDDFPKPQ ITVQPETQSA IKGSNLSFIC SAASSSDSPM TFAWKKDNEL LHDAEMENYA HLRAQGGEVM EYTTILRLRE VEFASEGKYQ CVISNHFGSS YSVKAKLTVN MLPSFTKTPM DLTIRAGAMA RLECAAVGHP APQIAWQKDG GTDFPAARER RMHVMPEDDV FFIVDVKIED IGVYSCTAQN SAGSISANAT LTVLETPSFL RPLLDRTVTK GETAVLQCIA GGSPPPKLNW TKDDSPLVVT ERHFFAAGNQ LLIIVDSDVS DAGKYTCEMS NTLGTERGNV RLSVIPTPTC DSPQMTAPSL DDDGWATVGV VIIAVVCCVV GTSLVWVVII YHTRRRNEDC SITNTDETNL PADIPSYLSS QGTLADRQDG YVSSESGSHH QFVTSSGAGF FLPQHDSSGT CHIDNSSEAD VEAATDLFLC PFLGSTGPMY LKGNVYGSDP FETYHTGCSP DPRTVLMDHY EPSYIKKKEC YPCSHPSEES CERSFSNISW PSHVRKLLNT SYSHNEGPGM KNLCLNKSSL DFSANPEPAS VASSNSFMGT FGKALRRPHL DAYSSFGQPS DCQPRAFYLK AHSSPDLDSG SEEDGKERTD FQEENHICTF KQTLENYRTP NFQSYDLDT