LRIG2_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 2

LRIG2_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 2
Magnify LRIG2_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRIG2_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 2 » LIG-2;
Hydrophobic Thickness 38.4 ± 4.2 Å
Tilt Angle 22 ± 0°
ΔGtransfer -28.6 kcal/mol
ΔGfold -22.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 802-830 (799-833)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 144-195, PDBID: 4U7L, Subunit A, Seq Identity:58%, Leucine rich repeat

AA: 240-299, PDBID: 4LI1, Subunit A, Seq Identity:38%, Leucine rich repeat

AA: 311-371, PDBID: 4U7L, Subunit A, Seq Identity:53%, Leucine rich repeat

AA: 468-493, PDBID: 4U7L, Subunit A, Seq Identity:60%, Leucine rich repeat C-terminal domain

AA: 497-584, PDBID: 3SO5, Subunit B, Seq Identity:55%, Immunoglobulin domain

AA: 602-692, PDBID: 4U7M, Subunit A, Seq Identity:79%, Immunoglobulin I-set domain

AA: 696-783, PDBID: 4U7M, Subunit A, Seq Identity:56%, Immunoglobulin I-set domain

UniProt annotation for LRIG2_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 2
TISSUE SPECIFICITY: Detected in all tissues analyzed.

DISEASE: Urofacial syndrome 2 (UFS2) OMIM: A rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure. mutations affecting the gene represented in this entry.

UniProt features for LRIG2_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 2
SIGNAL 1 40 Potential.
CHAIN 41 1065 Leucine-rich repeats and immunoglobulin- like domains protein 2.
DOMAIN 41 75 LRRNT.
REPEAT 76 97 LRR 1.
REPEAT 98 119 LRR 2.
REPEAT 121 142 LRR 3.
REPEAT 145 166 LRR 4.
REPEAT 168 189 LRR 5.
REPEAT 193 214 LRR 6.
REPEAT 216 237 LRR 7.
REPEAT 240 261 LRR 8.
REPEAT 264 285 LRR 9.
REPEAT 288 309 LRR 10.
REPEAT 312 333 LRR 11.
REPEAT 336 357 LRR 12.
REPEAT 360 382 LRR 13.
REPEAT 387 408 LRR 14.
REPEAT 411 432 LRR 15.
DOMAIN 443 494 LRRCT.
DOMAIN 498 597 Ig-like C2-type 1.
DOMAIN 602 691 Ig-like C2-type 2.
DOMAIN 696 785 Ig-like C2-type 3.
DISULFID 519 580 By similarity.
DISULFID 623 675 By similarity.
DISULFID 717 766 By similarity.
Amino Acid Sequence for LRIG2_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 2
MAPAPLGVPE EQLLGCRSRV LSRLLFIAQT ALLLLPAAGA GLCPAPCSCR IPLLDCSRRK LPAPSWRALS GLLPPDTAIL DFSHNRLSNW NISLESQTLQ EVKMNYNELT EIPYFGEPTS NITLLSLVHN IIPEINAQAL QFYPALESLD LSSNIISEIK TSSFPRMQLK YLNLSNNRIT TLEAGCFDNL SSSLLVVKLN RNRMSMIPPK IFKLPHLQFL ELKRNRIKIV EGLTFQGLDS LRSLKMQRNG ISKLKDGAFF GLNNMEELEL EHNNLTRVNK GWLYGLRMLQ QLYVSQNAIE RISPDAWEFC QRLSELDLSY NQLTRLDESA FVGLSLLERL NLGDNRVTHI ADGVFRFLSN LQTLDLRNNE ISWAIEDASE AFAGLTSLTK LILQGNQIKS ITKKAFIGLE SLEHLDLNNN AIMSIQENAF SQTHLKELIL NTSSLLCDCH LKWLLQWLVD NNFQHSVNVS CAHPEWLAGQ SILNVDLKDF VCDDFLKPQI RTHPETIIAL RGMNVTLTCT AVSSSDSPMS TVWRKDSEIL YDVDTENFVR YWQQAGEALE YTSILHLFNV NFTDEGKYQC IVTNHFGSNY SQKAKLTVNE MPSFLKTPMD LTIRTGAMAR LECAAEGHPA PQISWQKDGG TDFPAARERR MHVMPEDDVF FIANVKIEDM GIYSCMAQNT AGGLSANASL TVLETPSFIR PLEDKTVTRG ETAVLQCIAG GSPAPRLNWT KDDGPLLVTE RHFFAAANQL LIIVDAGLED AGKYTCIMSN TLGTERGHIY LNVISSPNCD SSQSSIGHED DGWTTVGIVI IVVVCCVVGT SLIWVIVIYH MRRKNEDYSI TNTEELNLPA DIPSYLSSQG TLSEPQEGYS NSEAGSHQQL MPPANGYIHK GTDGGTGTRV ICSDCYDNAN IYSRTREYCP YTYIAEEDVL DQTLSSLMVQ MPKETYLVHP PQDTTALESL IPSANREPSA FPTNHERISE KKLPSTQMSG ETLQRPVWNI NRELGLPHPP FSQQPVHESP QLHQNEGLAG REPDCSASSM SCHRLQDHAF DFSRTRNIQD GSEGT