LRIG1_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 1

LRIG1_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRIG1_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 1 » LIG-1;
Hydrophobic Thickness 37.2 ± 2.6 Å
Tilt Angle 1 ± 2°
ΔGtransfer -39.7 kcal/mol
ΔGfold -18.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 792-816 (791-824)
Pathways none
PDB none
OPM none
Complexes none
Interactions

EGFR, Complex: EGFR:LRIG1, PubMed

ERBB2, Complex: LRIG1:ERBB2, PubMed

ERBB3, Complex: LRIG1:ERBB3, PubMed

ERBB4, Complex: LRIG1:ERBB4, PubMed

MET, Complex: MET:LRIG1, PubMed

Domains

AA: 69-104, PDBID: 4U7L, Subunit A, Seq Identity:100%, Leucine rich repeat

AA: 140-189, PDBID: 4U7L, Subunit A, Seq Identity:100%, Leucine rich repeat

AA: 188-247, PDBID: 4U7L, Subunit A, Seq Identity:100%, Leucine rich repeat

AA: 307-367, PDBID: 4U7L, Subunit A, Seq Identity:100%, Leucine rich repeat

AA: 382-442, PDBID: 4U7L, Subunit A, Seq Identity:100%, Leucine rich repeat

AA: 465-490, PDBID: 4U7L, Subunit A, Seq Identity:100%, Leucine rich repeat C-terminal domain

AA: 494-581, PDBID: 4U7M, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 599-689, PDBID: 4U7M, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

AA: 693-780, PDBID: 4U7M, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

UniProt annotation for LRIG1_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 1
FUNCTION: Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.

SUBUNIT: Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4.

TISSUE SPECIFICITY: Widely expressed.

INDUCTION: By EGF.

DOMAIN: The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted.

UniProt features for LRIG1_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 1
SIGNAL 1 34 Potential.
CHAIN 35 1093 Leucine-rich repeats and immunoglobulin- like domains protein 1.
DOMAIN 35 68 LRRNT.
REPEAT 69 90 LRR 1.
REPEAT 93 114 LRR 2.
REPEAT 116 137 LRR 3.
REPEAT 140 161 LRR 4.
REPEAT 164 185 LRR 5.
REPEAT 189 210 LRR 6.
REPEAT 212 233 LRR 7.
REPEAT 236 257 LRR 8.
REPEAT 260 281 LRR 9.
REPEAT 284 305 LRR 10.
REPEAT 308 329 LRR 11.
REPEAT 332 353 LRR 12.
REPEAT 356 378 LRR 13.
REPEAT 383 404 LRR 14.
REPEAT 407 428 LRR 15.
DOMAIN 440 491 LRRCT.
DOMAIN 495 594 Ig-like C2-type 1.
DOMAIN 599 688 Ig-like C2-type 2.
DOMAIN 693 779 Ig-like C2-type 3.
DISULFID 516 577 By similarity.
DISULFID 620 672 By similarity.
DISULFID 714 763 By similarity.
Amino Acid Sequence for LRIG1_HUMAN » Leucine-rich repeats and immunoglobulin-like domains protein 1
MARPVRGGLG APRRSPCLLL LWLLLLRLEP VTAAAGPRAP CAAACTCAGD SLDCGGRGLA ALPGDLPSWT RSLNLSYNKL SEIDPAGFED LPNLQEVYLN NNELTAVPSL GAASSHVVSL FLQHNKIRSV EGSQLKAYLS LEVLDLSLNN ITEVRNTCFP HGPPIKELNL AGNRIGTLEL GAFDGLSRSL LTLRLSKNRI TQLPVRAFKL PRLTQLDLNR NRIRLIEGLT FQGLNSLEVL KLQRNNISKL TDGAFWGLSK MHVLHLEYNS LVEVNSGSLY GLTALHQLHL SNNSIARIHR KGWSFCQKLH ELVLSFNNLT RLDEESLAEL SSLSVLRLSH NSISHIAEGA FKGLRSLRVL DLDHNEISGT IEDTSGAFSG LDSLSKLTLF GNKIKSVAKR AFSGLEGLEH LNLGGNAIRS VQFDAFVKMK NLKELHISSD SFLCDCQLKW LPPWLIGRML QAFVTATCAH PESLKGQSIF SVPPESFVCD DFLKPQIITQ PETTMAMVGK DIRFTCSAAS SSSSPMTFAW KKDNEVLTNA DMENFVHVHA QDGEVMEYTT ILHLRQVTFG HEGRYQCVIT NHFGSTYSHK ARLTVNVLPS FTKTPHDITI RTTTMARLEC AATGHPNPQI AWQKDGGTDF PAARERRMHV MPDDDVFFIT DVKIDDAGVY SCTAQNSAGS ISANATLTVL ETPSLVVPLE DRVVSVGETV ALQCKATGNP PPRITWFKGD RPLSLTERHH LTPDNQLLVV QNVVAEDAGR YTCEMSNTLG TERAHSQLSV LPAAGCRKDG TTVGIFTIAV VSSIVLTSLV WVCIIYQTRK KSEEYSVTNT DETVVPPDVP SYLSSQGTLS DRQETVVRTE GGPQANGHIE SNGVCPRDAS HFPEPDTHSV ACRQPKLCAG SAYHKEPWKA MEKAEGTPGP HKMEHGGRVV CSDCNTEVDC YSRGQAFHPQ PVSRDSAQPS APNGPEPGGS DQEHSPHHQC SRTAAGSCPE CQGSLYPSNH DRMLTAVKKK PMASLDGKGD SSWTLARLYH PDSTELQPAS SLTSGSPERA EAQYLLVSNG HLPKACDASP ESTPLTGQLP GKQRVPLLLA PKS