LRFN5_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 5

LRFN5_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRFN5_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 5 »
Hydrophobic Thickness 42.8 ± 4.0 Å
Tilt Angle 8 ± 4°
ΔGtransfer -34.3 kcal/mol
ΔGfold -24.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 524-552 (521-553)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 64-198, PDBID: 3ZYJ, Subunit C, Seq Identity:34%, Leucine rich repeats (6 copies)

AA: 287-374, PDBID: 2ID5, Subunit D, Seq Identity:35%, Immunoglobulin I-set domain

UniProt annotation for LRFN5_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 5
FUNCTION: Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons.

SUBUNIT: Can form heteromeric complexes with LRFN1, LRFN2, LRFN3 and LFRN4. Able to form homomeric complexes across cell junctions, between adjacent cells. Does not interact with DLG1, DLG2, DLG3 and DLG4.

DOMAIN: Lacks a cytoplasmic PDZ-binding motif, which has been implicated in function of related LRFN proteins.

UniProt features for LRFN5_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 5
SIGNAL 1 17 Potential.
CHAIN 18 719 Leucine-rich repeat and fibronectin type- III domain-containing protein 5.
DOMAIN 18 51 LRRNT.
REPEAT 52 73 LRR 1.
REPEAT 76 97 LRR 2.
REPEAT 100 121 LRR 3.
REPEAT 124 145 LRR 4.
REPEAT 148 169 LRR 5.
REPEAT 172 193 LRR 6.
REPEAT 196 217 LRR 7.
DOMAIN 240 286 LRRCT.
DOMAIN 287 373 Ig-like.
DOMAIN 414 503 Fibronectin type-III.
DISULFID 308 357 By similarity.
Amino Acid Sequence for LRFN5_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 5
MEKILFYLFL IGIAVKAQIC PKRCVCQILS PNLATLCAKK GLLFVPPNID RRTVELRLAD NFVTNIKRKD FANMTSLVDL TLSRNTISFI TPHAFADLRN LRALHLNSNR LTKITNDMFS GLSNLHHLIL NNNQLTLISS TAFDDVFALE ELDLSYNNLE TIPWDAVEKM VSLHTLSLDH NMIDNIPKGT FSHLHKMTRL DVTSNKLQKL PPDPLFQRAQ VLATSGIISP STFALSFGGN PLHCNCELLW LRRLSREDDL ETCASPPLLT GRYFWSIPEE EFLCEPPLIT RHTHEMRVLE GQRATLRCKA RGDPEPAIHW ISPEGKLISN ATRSLVYDNG TLDILITTVK DTGAFTCIAS NPAGEATQIV DLHIIKLPHL LNSTNHIHEP DPGSSDISTS TKSGSNTSSS NGDTKLSQDK IVVAEATSST ALLKFNFQRN IPGIRMFQIQ YNGTYDDTLV YRMIPPTSKT FLVNNLAAGT MYDLCVLAIY DDGITSLTAT RVVGCIQFTT EQDYVRCHFM QSQFLGGTMI IIIGGIIVAS VLVFIIILMI RYKVCNNNGQ HKVTKVSNVY SQTNGAQIQG CSVTLPQSVS KQAVGHEENA QCCKATSDNV IQSSETCSSQ DSSTTTSALP PSWTSSTSVS QKQKRKTGTK PSTEPQNEAV TNVESQNTNR NNSTALQLAS RPPDSVTEGP TSKRAHIKPN ALLTNVDQIV QETQRLELI