LRFN4_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 4

LRFN4_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRFN4_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 4 »
Hydrophobic Thickness 34.0 ± 5.0 Å
Tilt Angle 30 ± 3°
ΔGtransfer -26.7 kcal/mol
ΔGfold -19.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 514-539 (508-542)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 48-108, PDBID: 1OZN, Subunit A, Seq Identity:40%, Leucine rich repeat

AA: 96-157, PDBID: 1GWB, Subunit B, Seq Identity:42%, Leucine rich repeat

AA: 120-181, PDBID: 4BSR, Subunit B, Seq Identity:43%, Leucine rich repeat

AA: 145-205, PDBID: 2WFH, Subunit A, Seq Identity:41%, Leucine rich repeat

AA: 281-368, PDBID: 2V9Q, Subunit A, Seq Identity:37%, Immunoglobulin I-set domain

AA: 407-484, PDBID: 2H41, Subunit A, Seq Identity:34%, Fibronectin type III domain

UniProt annotation for LRFN4_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 4
FUNCTION: Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity).

SUBUNIT: Can form heteromeric complexes with LRFN1, LRFN2, LRFN3 and LRFN5. Unable to form homophilic interactions across cell junctions (By similarity). Interacts with DLG1, DLG2, DLG3 and DLG4.

DOMAIN: The PDZ-binding motif is required for neurite outgrowth promotion (By similarity). This motif is also involved in DLG1-, DLG3- and DLG4-binding.

UniProt features for LRFN4_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 4
SIGNAL 1 16 Potential.
CHAIN 17 635 Leucine-rich repeat and fibronectin type- III domain-containing protein 4.
DOMAIN 17 48 LRRNT.
REPEAT 49 70 LRR 1.
REPEAT 73 94 LRR 2.
REPEAT 97 118 LRR 3.
REPEAT 121 142 LRR 4.
REPEAT 146 161 LRR 5.
REPEAT 170 191 LRR 6.
REPEAT 194 215 LRR 7.
DOMAIN 234 280 LRRCT.
DOMAIN 281 367 Ig-like.
DOMAIN 407 492 Fibronectin type-III.
MOTIF 632 635 PDZ-binding.
DISULFID 302 351 By similarity.
Amino Acid Sequence for LRFN4_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 4
MAPPLLLLLL ASGAAACPLP CVCQNLSESL STLCAHRGLL FVPPNVDRRT VELRLADNFI QALGPPDFRN MTGLVDLTLS RNAITRIGAR AFGDLESLRS LHLDGNRLVE LGTGSLRGPV NLQHLILSGN QLGRIAPGAF DDFLESLEDL DLSYNNLRQV PWAGIGAMPA LHTLNLDHNL IDALPPGAFA QLGQLSRLDL TSNRLATLAP DPLFSRGRDA EASPAPLVLS FSGNPLHCNC ELLWLRRLAR PDDLETCASP PGLAGRYFWA VPEGEFSCEP PLIARHTQRL WVLEGQRATL RCRALGDPAP TMHWVGPDDR LVGNSSRARA FPNGTLEIGV TGAGDAGGYT CIATNPAGEA TARVELRVLA LPHGGNSSAE GGRPGPSDIA ASARTAAEGE GTLESEPAVQ VTEVTATSGL VSWGPGRPAD PVWMFQIQYN SSEDETLIYR IVPASSHHFL LKHLVPGADY DLCLLALSPA AGPSDLTATR LLGCAHFSTL PASPLCHALQ AHVLGGTLTV AVGGVLVAAL LVFTVALLVR GRGAGNGRLP LKLSHVQSQT NGGPSPTPKA HPPRSPPPRP QRSCSLDLGD AGCYGYARRL GGAWARRSHS VHGGLLGAGC RGVGGSAERL EESVV