LRFN3_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 3

LRFN3_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRFN3_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 3 » Synaptic adhesion-like molecule 4;
Hydrophobic Thickness 35.2 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -49.0 kcal/mol
ΔGfold -22.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 534-562 (534-563)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 109-157, PDBID: 4CNC, Subunit B, Seq Identity:50%, Leucine rich repeat

AA: 131-192, PDBID: 4BV4, Subunit R, Seq Identity:39%, Leucine rich repeat

AA: 156-216, PDBID: 1OZN, Subunit A, Seq Identity:42%, Leucine rich repeat

AA: 180-232, PDBID: 4CNC, Subunit B, Seq Identity:46%, Leucine rich repeat

AA: 296-383, PDBID: 2V9Q, Subunit A, Seq Identity:40%, Immunoglobulin I-set domain

AA: 424-508, PDBID: 2H41, Subunit A, Seq Identity:29%, Fibronectin type III domain

UniProt annotation for LRFN3_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 3
FUNCTION: Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity).

SUBUNIT: Can form heteromeric complexes with LRFN1, LRFN2, LRFN4 and LRFN5. Able to form homomeric complexes across cell junctions, between adjacent cells. Does not interact with DLG4 (By similarity).

DOMAIN: Lacks a cytoplasmic PDZ-binding domain, which has been implicated in function of related Lrfn proteins.

UniProt features for LRFN3_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 3
SIGNAL 1 16 Potential.
CHAIN 17 628 Leucine-rich repeat and fibronectin type- III domain-containing protein 3.
DOMAIN 19 59 LRRNT.
REPEAT 60 83 LRR 1.
REPEAT 84 105 LRR 2.
REPEAT 108 129 LRR 3.
REPEAT 132 153 LRR 4.
REPEAT 157 178 LRR 5.
REPEAT 181 202 LRR 6.
REPEAT 205 226 LRR 7.
DOMAIN 249 295 LRRCT.
DOMAIN 295 382 Ig-like.
DOMAIN 425 515 Fibronectin type-III.
DISULFID 317 366 By similarity.
Amino Acid Sequence for LRFN3_HUMAN » Leucine-rich repeat and fibronectin type-III domain-containing protein 3
MAILPLLLCL LPLAPASSPP QSATPSPCPR RCRCQTQSLP LSVLCPGAGL LFVPPSLDRR AAELRLADNF IASVRRRDLA NMTGLLHLSL SRNTIRHVAA GAFADLRALR ALHLDGNRLT SLGEGQLRGL VNLRHLILSN NQLAALAAGA LDDCAETLED LDLSYNNLEQ LPWEALGRLG NVNTLGLDHN LLASVPAGAF SRLHKLARLD MTSNRLTTIP PDPLFSRLPL LARPRGSPAS ALVLAFGGNP LHCNCELVWL RRLAREDDLE ACASPPALGG RYFWAVGEEE FVCEPPVVTH RSPPLAVPAG RPAALRCRAV GDPEPRVRWV SPQGRLLGNS SRARAFPNGT LELLVTEPGD GGIFTCIAAN AAGEATAAVE LTVGPPPPPQ LANSTSCDPP RDGDPDALTP PSAASASAKV ADTGPPTDRG VQVTEHGATA ALVQWPDQRP IPGIRMYQIQ YNSSADDILV YRMIPAESRS FLLTDLASGR TYDLCVLAVY EDSATGLTAT RPVGCARFST EPALRPCGAP HAPFLGGTMI IALGGVIVAS VLVFIFVLLM RYKVHGGQPP GKAKIPAPVS SVCSQTNGAL GPTPTPAPPA PEPAALRAHT VVQLDCEPWG PGHEPVGP