LRFN1_HUMAN » Leucine-rich repeat and fibronectin type III domain-containing protein 1

LRFN1_HUMAN » Leucine-rich repeat and fibronectin type III domain-containing protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRFN1_HUMAN » Leucine-rich repeat and fibronectin type III domain-containing protein 1 » Synaptic adhesion-like molecule 2;
Hydrophobic Thickness 32.8 ± 1.4 Å
Tilt Angle 1 ± 1°
ΔGtransfer -49.9 kcal/mol
ΔGfold -22.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 531-559 (531-562)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 162-222, PDBID: 4U7L, Subunit A, Seq Identity:42%, Leucine rich repeat

AA: 299-387, PDBID: 2ID5, Subunit D, Seq Identity:35%, Immunoglobulin I-set domain

AA: 423-504, PDBID: 2H41, Subunit A, Seq Identity:31%, Fibronectin type III domain

UniProt annotation for LRFN1_HUMAN » Leucine-rich repeat and fibronectin type III domain-containing protein 1
FUNCTION: Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity).

SUBUNIT: Can form heteromeric complexes with LRFN2, LRFN3, LRFN4 and LRFN5 (By similarity). Forms homomeric complexes, but not across cell junctions (By similarity). Interacts with DLG1, DLG2, DLG3 and DLG4. Interacts with 2 AMPA receptor subunits GRIA1 and GRIA2 and NMDA receptor subunit GRIN1 (By similarity).

DOMAIN: The PDZ-binding motif is required for neurite outgrowth promotion and for DLG1-, DLG3- and DLG4-binding.

UniProt features for LRFN1_HUMAN » Leucine-rich repeat and fibronectin type III domain-containing protein 1
SIGNAL 1 31 Potential.
CHAIN 32 771 Leucine-rich repeat and fibronectin type III domain-containing protein 1.
DOMAIN 32 65 LRRNT.
REPEAT 66 87 LRR 1.
REPEAT 90 111 LRR 2.
REPEAT 114 135 LRR 3.
REPEAT 138 159 LRR 4.
REPEAT 163 184 LRR 5.
REPEAT 187 208 LRR 6.
REPEAT 211 232 LRR 7.
DOMAIN 252 298 LRRCT.
DOMAIN 299 386 Ig-like.
DOMAIN 421 512 Fibronectin type-III.
MOTIF 768 771 PDZ-binding.
DISULFID 321 370 By similarity.
Amino Acid Sequence for LRFN1_HUMAN » Leucine-rich repeat and fibronectin type III domain-containing protein 1
MAPGPFSSAL LSPPPAALPF LLLLWAGASR GQPCPGRCIC QNVAPTLTML CAKTGLLFVP PAIDRRVVEL RLTDNFIAAV RRRDFANMTS LVHLTLSRNT IGQVAAGAFA DLRALRALHL DSNRLAEVRG DQLRGLGNLR HLILGNNQIR RVESAAFDAF LSTVEDLDLS YNNLEALPWE AVGQMVNLNT LTLDHNLIDH IAEGTFVQLH KLVRLDMTSN RLHKLPPDGL FLRSQGTGPK PPTPLTVSFG GNPLHCNCEL LWLRRLTRED DLETCATPEH LTDRYFWSIP EEEFLCEPPL ITRQAGGRAL VVEGQAVSLR CRAVGDPEPV VHWVAPDGRL LGNSSRTRVR GDGTLDVTIT TLRDSGTFTC IASNAAGEAT APVEVCVVPL PLMAPPPAAP PPLTEPGSSD IATPGRPGAN DSAAERRLVA AELTSNSVLI RWPAQRPVPG IRMYQVQYNS SVDDSLVYRM IPSTSQTFLV NDLAAGRAYD LCVLAVYDDG ATALPATRVV GCVQFTTAGD PAPCRPLRAH FLGGTMIIAI GGVIVASVLV FIVLLMIRYK VYGDGDSRRV KGSRSLPRVS HVCSQTNGAG TGAAQAPALP AQDHYEALRE VESQAAPAVA VEAKAMEAET ASAEPEVVLG RSLGGSATSL CLLPSEETSG EESRAAVGPR RSRSGALEPP TSAPPTLALV PGGAAARPRP QQRYSFDGDY GALFQSHSYP RRARRTKRHR STPHLDGAGG GAAGEDGDLG LGSARACLAF TSTEWMLEST V