LRC59_HUMAN » Leucine-rich repeat-containing protein 59

LRC59_HUMAN » Leucine-rich repeat-containing protein 59
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
LRC59_HUMAN » Leucine-rich repeat-containing protein 59 » Ribosome-binding protein p34;p34;
Hydrophobic Thickness 23.6 ± 2.0 Å
Tilt Angle 2 ± 1°
ΔGtransfer -30.4 kcal/mol
ΔGfold -17.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 245-266 (245-267)
Pathways none
PDB none
OPM none
Complexes none
Interactions

1B07, Complex: 1B07:LRC59, PubMed

1B42, Complex: 1B42:LRC59, PubMed

A4, Complex: LRC59:A4, PubMed

EGFR, Complex: LRC59:EGFR, PubMed

ESR1, Complex: LRC59:ESR1, PubMed

ITA4, Complex: LRC59:ITA4, PubMed

TNR1A, Complex: TNR1A:LRC59, PubMed

VCAM1, Complex: VCAM1:LRC59

Domains

AA: 18-74, PDBID: 3WPE, Subunit A, Seq Identity:42%, Leucine rich repeat

AA: 63-120, PDBID: 4CNC, Subunit B, Seq Identity:47%, Leucine rich repeat

UniProt annotation for LRC59_HUMAN » Leucine-rich repeat-containing protein 59
FUNCTION: Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.

SUBUNIT: Can form homodimers. Interacts with SGOL1. Interacts with FGF1.

TISSUE SPECIFICITY: Widely expressed.

UniProt features for LRC59_HUMAN » Leucine-rich repeat-containing protein 59
CHAIN 1 307 Leucine-rich repeat-containing protein 59.
REPEAT 10 31 LRR 1.
REPEAT 40 62 LRR 2.
REPEAT 63 84 LRR 3.
REPEAT 86 107 LRR 4.
REPEAT 109 128 LRR 5.
COILED 148 216 Potential.
Amino Acid Sequence for LRC59_HUMAN » Leucine-rich repeat-containing protein 59
MTKAGSKGGN LRDKLDGNEL DLSLSDLNEV PVKELAALPK ATILDLSCNK LTTLPSDFCG LTHLVKLDLS KNKLQQLPAD FGRLVNLQHL DLLNNKLVTL PVSFAQLKNL KWLDLKDNPL DPVLAKVAGD CLDEKQCKQC ANKVLQHMKA VQADQERERQ RRLEVEREAE KKREAKQRAK EAQERELRKR EKAEEKERRR KEYDALKAAK REQEKKPKKE ANQAPKSKSG SRPRKPPPRK HTRSWAVLKL LLLLLLFGVA GGLVACRVTE LQQQPLCTSV NTIYDNAVQG LRRHEILQWV LQTDSQQ