LRC4C_HUMAN » Leucine-rich repeat-containing protein 4C

LRC4C_HUMAN » Leucine-rich repeat-containing protein 4C
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRC4C_HUMAN » Leucine-rich repeat-containing protein 4C » Netrin-G1 ligand;NGL-1;
Hydrophobic Thickness 37.6 ± 4.4 Å
Tilt Angle 0 ± 20°
ΔGtransfer -32.9 kcal/mol
ΔGfold -26.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 525-550 (521-551)
Pathways

Axon guidance (KEGG)

Cell adhesion molecules (KEGG)

PDB 3zyj (A/C=44-444)
OPM none
Complexes none
Interactions

CR3L4, Complex: LRC4C:CR3L4, PubMed

Domains

AA: 76-216, PDBID: 3ZYJ, Subunit C, Seq Identity:100%, Leucine rich repeats (6 copies)

AA: 244-302, PDBID: 3ZYJ, Subunit A, Seq Identity:100%, Leucine rich repeat

AA: 354-443, PDBID: 3ZYJ, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

UniProt annotation for LRC4C_HUMAN » Leucine-rich repeat-containing protein 4C
FUNCTION: May promote neurite outgrowth of developing thalamic neurons.

SUBUNIT: Interacts with NTNG1 and WHRN.

TISSUE SPECIFICITY: Highly expressed in the cerebral cortex, including frontal, parietal and occipital lobes. Putamen, amygdala, hippocampus and medulla oblongata show moderate expression. Caudate nucleus and thalamus express small amounts, whereas other brain regions show very weak or no expression.

DOMAIN: The LRR region is both necessary and sufficient for the interaction with NTNG1.

UniProt features for LRC4C_HUMAN » Leucine-rich repeat-containing protein 4C
SIGNAL 1 44 Potential.
CHAIN 45 640 Leucine-rich repeat-containing protein 4C.
DOMAIN 45 76 LRRNT.
REPEAT 77 98 LRR 1.
REPEAT 101 122 LRR 2.
REPEAT 125 146 LRR 3.
REPEAT 149 170 LRR 4.
REPEAT 173 195 LRR 5.
REPEAT 198 219 LRR 6.
REPEAT 220 241 LRR 7.
REPEAT 244 265 LRR 8.
REPEAT 268 289 LRR 9.
DOMAIN 301 353 LRRCT.
DOMAIN 354 442 Ig-like C2-type.
DISULFID 375 426 By similarity.
Amino Acid Sequence for LRC4C_HUMAN » Leucine-rich repeat-containing protein 4C
MLNKMTLHPQ QIMIGPRFNR ALFDPLLVVL LALQLLVVAG LVRAQTCPSV CSCSNQFSKV ICVRKNLREV PDGISTNTRL LNLHENQIQI IKVNSFKHLR HLEILQLSRN HIRTIEIGAF NGLANLNTLE LFDNRLTTIP NGAFVYLSKL KELWLRNNPI ESIPSYAFNR IPSLRRLDLG ELKRLSYISE GAFEGLSNLR YLNLAMCNLR EIPNLTPLIK LDELDLSGNH LSAIRPGSFQ GLMHLQKLWM IQSQIQVIER NAFDNLQSLV EINLAHNNLT LLPHDLFTPL HHLERIHLHH NPWNCNCDIL WLSWWIKDMA PSNTACCARC NTPPNLKGRY IGELDQNYFT CYAPVIVEPP ADLNVTEGMA AELKCRASTS LTSVSWITPN GTVMTHGAYK VRIAVLSDGT LNFTNVTVQD TGMYTCMVSN SVGNTTASAT LNVTAATTTP FSYFSTVTVE TMEPSQDEAR TTDNNVGPTP VVDWETTNVT TSLTPQSTRS TEKTFTIPVT DINSGIPGID EVMKTTKIII GCFVAITLMA AVMLVIFYKM RKQHHRQNHH APTRTVEIIN VDDEITGDTP MESHLPMPAI EHEHLNHYNS YKSPFNHTTT VNTINSIHSS VHEPLLIRMN SKDNVQETQI