LRC4B_HUMAN » Leucine-rich repeat-containing protein 4B

LRC4B_HUMAN » Leucine-rich repeat-containing protein 4B
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRC4B_HUMAN » Leucine-rich repeat-containing protein 4B » Netrin-G3 ligand;NGL-3;
Hydrophobic Thickness 37.6 ± 4.4 Å
Tilt Angle 4 ± 17°
ΔGtransfer -32.8 kcal/mol
ΔGfold -25.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 574-599 (570-600)
Pathways

Cell adhesion molecules (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 86-146, PDBID: 3ZYN, Subunit A, Seq Identity:98%, Leucine rich repeat

AA: 224-265, PDBID: 3ZYN, Subunit A, Seq Identity:100%, Leucine rich repeat

AA: 257-312, PDBID: 3ZYN, Subunit A, Seq Identity:100%, Leucine rich repeat

AA: 364-453, PDBID: 3ZYO, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

UniProt annotation for LRC4B_HUMAN » Leucine-rich repeat-containing protein 4B
FUNCTION: Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).

SUBUNIT: Interacts with PTPRF. Interacts with DLG4.

DOMAIN: The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4.

UniProt features for LRC4B_HUMAN » Leucine-rich repeat-containing protein 4B
SIGNAL 1 35 Potential.
CHAIN 36 713 Leucine-rich repeat-containing protein 4B.
DOMAIN 48 86 LRRNT.
REPEAT 87 108 LRR 1.
REPEAT 111 132 LRR 2.
REPEAT 135 156 LRR 3.
REPEAT 159 180 LRR 4.
REPEAT 183 205 LRR 5.
REPEAT 208 229 LRR 6.
REPEAT 230 251 LRR 7.
REPEAT 254 275 LRR 8.
REPEAT 278 299 LRR 9.
DOMAIN 311 363 LRRCT.
DOMAIN 364 452 Ig-like C2-type.
DISULFID 385 436 By similarity.
Amino Acid Sequence for LRC4B_HUMAN » Leucine-rich repeat-containing protein 4B
MARARGSPCP PLPPGRMSWP HGALLFLWLF SPPLGAGGGG VAVTSAAGGG SPPATSCPVA CSCSNQASRV ICTRRDLAEV PASIPVNTRY LNLQENGIQV IRTDTFKHLR HLEILQLSKN LVRKIEVGAF NGLPSLNTLE LFDNRLTTVP TQAFEYLSKL RELWLRNNPI ESIPSYAFNR VPSLRRLDLG ELKRLEYISE AAFEGLVNLR YLNLGMCNLK DIPNLTALVR LEELELSGNR LDLIRPGSFQ GLTSLRKLWL MHAQVATIER NAFDDLKSLE ELNLSHNNLM SLPHDLFTPL HRLERVHLNH NPWHCNCDVL WLSWWLKETV PSNTTCCARC HAPAGLKGRY IGELDQSHFT CYAPVIVEPP TDLNVTEGMA AELKCRTGTS MTSVNWLTPN GTLMTHGSYR VRISVLHDGT LNFTNVTVQD TGQYTCMVTN SAGNTTASAT LNVSAVDPVA AGGTGSGGGG PGGSGGVGGG SGGYTYFTTV TVETLETQPG EEALQPRGTE KEPPGPTTDG VWGGGRPGDA AGPASSSTTA PAPRSSRPTE KAFTVPITDV TENALKDLDD VMKTTKIIIG CFVAITFMAA VMLVAFYKLR KQHQLHKHHG PTRTVEIINV EDELPAASAV SVAAAAAVAS GGGVGGDSHL ALPALERDHL NHHHYVAAAF KAHYSSNPSG GGCGGKGPPG LNSIHEPLLF KSGSKENVQE TQI