LRC33_HUMAN » Negative regulator of reactive oxygen species

LRC33_HUMAN » Negative regulator of reactive oxygen species
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRC33_HUMAN » Negative regulator of reactive oxygen species »
Hydrophobic Thickness 38.0 ± 1.2 Å
Tilt Angle 1 ± 0°
ΔGtransfer -35.3 kcal/mol
ΔGfold -18.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 648-676 (648-676)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 157-217, PDBID: 2z64, Subunit A, Seq Identity:31%, Leucine rich repeat

AA: 376-438, PDBID: 2z64, Subunit A, Seq Identity:36%, Leucine rich repeat

AA: 536-552, PDBID: 3g06, Subunit A, Seq Identity:52%, Leucine rich repeat

AA: 559-579, PDBID: 3a79, Subunit B, Seq Identity:46%, Leucine Rich Repeat

UniProt annotation for LRC33_HUMAN » Negative regulator of reactive oxygen species
FUNCTION: Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.

SUBUNIT: Interacts with CYBB/NOX2; the interaction is direct (By similarity). Interacts (via LRR repeats) with TLR2, TLR3, TLR4, TLR9 and probably other Toll-like receptors.

TISSUE SPECIFICITY: Ubiquitous, with high level of expression found in bone marrow, thymus, liver, lung, intestine and spleen.

UniProt features for LRC33_HUMAN » Negative regulator of reactive oxygen species
SIGNAL 1 18 Potential.
CHAIN 19 692 Leucine-rich repeat-containing protein 33.
REPEAT 58 79 LRR 1.
REPEAT 82 103 LRR 2.
REPEAT 106 127 LRR 3.
REPEAT 133 155 LRR 4.
REPEAT 158 179 LRR 5.
REPEAT 182 203 LRR 6.
REPEAT 206 227 LRR 7.
REPEAT 228 239 LRR 8.
REPEAT 251 272 LRR 9.
REPEAT 273 294 LRR 10.
REPEAT 329 350 LRR 11.
REPEAT 353 374 LRR 12.
REPEAT 377 398 LRR 13.
REPEAT 403 424 LRR 14.
REPEAT 427 447 LRR 15.
REPEAT 463 484 LRR 16.
REPEAT 486 507 LRR 17.
REPEAT 512 534 LRR 18.
REPEAT 537 558 LRR 19.
REPEAT 559 580 LRR 20.
REPEAT 585 594 LRR 21.
Amino Acid Sequence for LRC33_HUMAN » Negative regulator of reactive oxygen species
MELLPLWLCL GFHFLTVGWR NRSGTATAAS QGVCKLVGGA ADCRGQSLAS VPSSLPPHAR MLTLDANPLK TLWNHSLQPY PLLESLSLHS CHLERISRGA FQEQGHLRSL VLGDNCLSEN YEETAAALHA LPGLRRLDLS GNALTEDMAA LMLQNLSSLR SVSLAGNTIM RLDDSVFEGL ERLRELDLQR NYIFEIEGGA FDGLAELRHL NLAFNNLPCI VDFGLTRLRV LNVSYNVLEW FLATGGEAAF ELETLDLSHN QLLFFPLLPQ YSKLRTLLLR DNNMGFYRDL YNTSSPREMV AQFLLVDGNV TNITTVSLWE EFSSSDLADL RFLDMSQNQF QYLPDGFLRK MPSLSHLNLH QNCLMTLHIR EHEPPGALTE LDLSHNQLSE LHLAPGLASC LGSLRLFNLS SNQLLGVPPG LFANARNITT LDMSHNQISL CPLPAASDRV GPPSCVDFRN MASLRSLSLE GCGLGALPDC PFQGTSLTYL DLSSNWGVLN GSLAPLQDVA PMLQVLSLRN MGLHSSFMAL DFSGFGNLRD LDLSGNCLTT FPRFGGSLAL ETLDLRRNSL TALPQKAVSE QLSRGLRTIY LSQNPYDCCG VDGWGALQHG QTVADWAMVT CNLSSKIIRV TELPGGVPRD CKWERLDLGL LYLVLILPSC LTLLVACTVI VLTFKKPLLQ VIKSRCHWSS VY