LRC32_HUMAN » Leucine-rich repeat-containing protein 32

LRC32_HUMAN » Leucine-rich repeat-containing protein 32
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRC32_HUMAN » Leucine-rich repeat-containing protein 32 » Garpin;Glycoprotein A repetitions predominant;GARP;
Hydrophobic Thickness 35.6 ± 4.6 Å
Tilt Angle 0 ± 16°
ΔGtransfer -25.3 kcal/mol
ΔGfold -21.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 627-651 (626-654)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 21-48, PDBID: 1XCD, Subunit A, Seq Identity:36%, Leucine rich repeat N-terminal domain

AA: 49-109, PDBID: 2Z62, Subunit A, Seq Identity:43%, Leucine rich repeat

AA: 149-209, PDBID: 4U7L, Subunit A, Seq Identity:42%, Leucine rich repeat

AA: 514-573, PDBID: 4P8S, Subunit A, Seq Identity:41%, Leucine rich repeat

UniProt annotation for LRC32_HUMAN » Leucine-rich repeat-containing protein 32
TISSUE SPECIFICITY: Preferentially expressed in regulatory T-cells (T(regs)).
UniProt features for LRC32_HUMAN » Leucine-rich repeat-containing protein 32
SIGNAL 1 19
CHAIN 20 662 Leucine-rich repeat-containing protein 32.
REPEAT 50 73 LRR 1.
REPEAT 74 95 LRR 2.
REPEAT 98 119 LRR 3.
REPEAT 125 145 LRR 4.
REPEAT 150 171 LRR 5.
REPEAT 174 195 LRR 6.
REPEAT 198 219 LRR 7.
REPEAT 220 240 LRR 8.
REPEAT 244 265 LRR 9.
REPEAT 266 286 LRR 10.
REPEAT 316 339 LRR 11.
REPEAT 340 363 LRR 12.
REPEAT 364 385 LRR 13.
REPEAT 387 408 LRR 14.
REPEAT 411 432 LRR 15.
REPEAT 444 465 LRR 16.
REPEAT 467 488 LRR 17.
REPEAT 492 513 LRR 18.
REPEAT 515 536 LRR 19.
REPEAT 537 558 LRR 20.
DOMAIN 571 620 LRRCT.
Amino Acid Sequence for LRC32_HUMAN » Leucine-rich repeat-containing protein 32
MRPQILLLLA LLTLGLAAQH QDKVPCKMVD KKVSCQVLGL LQVPSVLPPD TETLDLSGNQ LRSILASPLG FYTALRHLDL STNEISFLQP GAFQALTHLE HLSLAHNRLA MATALSAGGL GPLPRVTSLD LSGNSLYSGL LERLLGEAPS LHTLSLAENS LTRLTRHTFR DMPALEQLDL HSNVLMDIED GAFEGLPRLT HLNLSRNSLT CISDFSLQQL RVLDLSCNSI EAFQTASQPQ AEFQLTWLDL RENKLLHFPD LAALPRLIYL NLSNNLIRLP TGPPQDSKGI HAPSEGWSAL PLSAPSGNAS GRPLSQLLNL DLSYNEIELI PDSFLEHLTS LCFLNLSRNC LRTFEARRLG SLPCLMLLDL SHNALETLEL GARALGSLRT LLLQGNALRD LPPYTFANLA SLQRLNLQGN RVSPCGGPDE PGPSGCVAFS GITSLRSLSL VDNEIELLRA GAFLHTPLTE LDLSSNPGLE VATGALGGLE ASLEVLALQG NGLMVLQVDL PCFICLKRLN LAENRLSHLP AWTQAVSLEV LDLRNNSFSL LPGSAMGGLE TSLRRLYLQG NPLSCCGNGW LAAQLHQGRV DVDATQDLIC RFSSQEEVSL SHVRPEDCEK GGLKNINLII ILTFILVSAI LLTTLAACCC VRRQKFNQQY KA