LRAD4_HUMAN » Low-density lipoprotein receptor class A domain-containing protein 4

LRAD4_HUMAN » Low-density lipoprotein receptor class A domain-containing protein 4
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Topology in Endosome membrane
Topologyendosome lumenal side
cytoplasmic side
LRAD4_HUMAN » Low-density lipoprotein receptor class A domain-containing protein 4 »
Hydrophobic Thickness 39.2 ± 2.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -51.9 kcal/mol
ΔGfold -27.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 62-90 (62-94)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 13-47, PDBID: 3T5O, Subunit A, Seq Identity:56%, Low-density lipoprotein receptor domain class A

UniProt annotation for LRAD4_HUMAN » Low-density lipoprotein receptor class A domain-containing protein 4
FUNCTION: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.

SUBUNIT: Interacts with PMEPA1. Interacts (via the SMAD interaction motif) with SMAD2 and SMAD3.

TISSUE SPECIFICITY: Expressed in lymphocytes.

DOMAIN: The SMAD interaction motif is required for interaction with SMAD2 and SMAD3 and the negative regulation of TGF-beta signaling.

UniProt features for LRAD4_HUMAN » Low-density lipoprotein receptor class A domain-containing protein 4
CHAIN 1 306 Low-density lipoprotein receptor class A domain-containing protein 4.
DOMAIN 16 48 LDL-receptor class A.
DISULFID 19 38 By similarity.
DISULFID 32 47 By similarity.
Amino Acid Sequence for LRAD4_HUMAN » Low-density lipoprotein receptor class A domain-containing protein 4
MPEAGFQATN AFTECKFTCT SGKCLYLGSL VCNQQNDCGD NSDEENCLLV TEHPPPGIFN SELEFAQIII IVVVVTVMVV VIVCLLNHYK VSTRSFINRP NQSRRREDGL PQEGCLWPSD SAAPRLGASE IMHAPRSRDR FTAPSFIQRD RFSRFQPTYP YVQHEIDLPP TISLSDGEEP PPYQGPCTLQ LRDPEQQMEL NRESVRAPPN RTIFDSDLID IAMYSGGPCP PSSNSGISAS TCSSNGRMEG PPPTYSEVMG HHPGASFLHH QRSNAHRGSR LQFQQNNAES TIVPIKGKDR KPGNLV