LRAD3_HUMAN » Low-density lipoprotein receptor class A domain-containing protein 3

LRAD3_HUMAN » Low-density lipoprotein receptor class A domain-containing protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRAD3_HUMAN » Low-density lipoprotein receptor class A domain-containing protein 3 »
Hydrophobic Thickness 33.6 ± 1.3 Å
Tilt Angle 1 ± 7°
ΔGtransfer -25.3 kcal/mol
ΔGfold -22.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 174-196 (168-199)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 27-64, PDBID: 1AJJ, Subunit A, Seq Identity:52%, Low-density lipoprotein receptor domain class A

AA: 69-106, PDBID: 1AJJ, Subunit A, Seq Identity:50%, Low-density lipoprotein receptor domain class A

AA: 111-147, PDBID: 1AJJ, Subunit A, Seq Identity:50%, Low-density lipoprotein receptor domain class A

UniProt annotation for LRAD3_HUMAN » Low-density lipoprotein receptor class A domain-containing protein 3
FUNCTION: May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.

SUBUNIT: Interacts with APP precursor C-terminus.

TISSUE SPECIFICITY: Expressed at high levels in brain, lung, skeletal muscle, and pancreas. Expressed at moderate levels in heart, placenta, and kidney but not detected in the liver.

UniProt features for LRAD3_HUMAN » Low-density lipoprotein receptor class A domain-containing protein 3
SIGNAL 1 17 Potential.
CHAIN 18 345 Low-density lipoprotein receptor class A domain-containing protein 3.
DOMAIN 28 65 LDL-receptor class A 1.
DOMAIN 70 107 LDL-receptor class A 2.
DOMAIN 112 148 LDL-receptor class A 3.
DISULFID 29 42 By similarity.
DISULFID 37 55 By similarity.
DISULFID 49 64 By similarity.
DISULFID 71 84 By similarity.
DISULFID 78 97 By similarity.
DISULFID 91 106 By similarity.
DISULFID 113 125 By similarity.
DISULFID 120 138 By similarity.
DISULFID 132 147 By similarity.
Amino Acid Sequence for LRAD3_HUMAN » Low-density lipoprotein receptor class A domain-containing protein 3
MWLLGPLCLL LSSAAESQLL PGNNFTNECN IPGNFMCSNG RCIPGAWQCD GLPDCFDKSD EKECPKAKSK CGPTFFPCAS GIHCIIGRFR CNGFEDCPDG SDEENCTANP LLCSTARYHC KNGLCIDKSF ICDGQNNCQD NSDEESCESS QEPGSGQVFV TSENQLVYYP SITYAIIGSS VIFVLVVALL ALVLHHQRKR NNLVTLPVHR LQHPVLLSRL VVLDHPHHCN VTYNVNNGIQ YVASQAEQNA SEVGSPPSYS EALLDQRPAW YDLPPPPYSS DTESLNQADL PPYRSRSGSA NSASSQAASS LLSVEDTSRS PGQPGPQEGT AEPRDSEPSQ GTEEV