LMTK2_HUMAN » Serine/threonine-protein kinase LMTK2

LMTK2_HUMAN » Serine/threonine-protein kinase LMTK2
Magnify LMTK2_HUMAN » Serine/threonine-protein kinase LMTK2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Endosome membrane
Topologyendosome lumenal side
cytoplasmic side
LMTK2_HUMAN » Serine/threonine-protein kinase LMTK2 » Apoptosis-associated tyrosine kinase 2;Brain-enriched kinase;hBREK; CDK5/p35-regulated kinase;CPRK; Kinase/phosphatase/inhibitor 2;Lemur tyrosine kinase 2;Serine/threonine-protein kinase KPI-2;
Hydrophobic Thickness 30.8 ± 2.8 Å
Tilt Angle 1 ± 5°
ΔGtransfer -33.9 kcal/mol
ΔGfold -16.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 44-66 (40-70)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 137-407, PDBID: 1XBA, Subunit A, Seq Identity:34%, Protein tyrosine kinase

UniProt annotation for LMTK2_HUMAN » Serine/threonine-protein kinase LMTK2
FUNCTION: Phosphorylates PPP1C, phosphorylase b and CFTR.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

SUBUNIT: Interacts with PPP1C and inhibitor-2.

TISSUE SPECIFICITY: Mainly expressed in skeletal muscle, and weakly in brain and pancreas.

UniProt features for LMTK2_HUMAN » Serine/threonine-protein kinase LMTK2
CHAIN 1 1503 Serine/threonine-protein kinase LMTK2.
DOMAIN 137 407 Protein kinase.
ACT_SITE 265 265 Proton acceptor (By similarity).
Amino Acid Sequence for LMTK2_HUMAN » Serine/threonine-protein kinase LMTK2
MPGPPALRRR LLLLLLVLLI AGSAGAAPLP QTGAGEAPPA AEVSSSFVIL CVCSLIILIV LIANCVSCCK DPEIDFKEFE DNFDDEIDFT PPAEDTPSVQ SPAEVFTLSV PNISLPAPSQ FQPSVEGLKS QVARHSLNYI QEIGNGWFGK VLLGEIYTGT SVARVIVKEL KASANPKEQD TFLKNGEPYY ILQHPNILQC VGQCVEAIPY LLVFEFCDLG DLKAYLRSEQ EHMRGDSQTM LLQRMACEVA AGLAAMHKLH FLHSDLALRN CFLTSDLNVK VGDYGIGFSR YKEDYIETDD KKVFPLRWTA PELVTSFQDR LLTADQTKYS NIWSLGVTLW ELFDNAAQPY SNLSNLDVLN QVIRERDTKL PKPQLEQPYS DRWYEVLQFC WLSPEKRPAA EDVHRLLTYL RLQSQRDSEV DFEQQWNALK PNTNSRDSSN NAAFPILDHF ARDRLGREME EVLTVTETSQ GLSFEYVWEA AKHDHFDERS RGHLDEGLSY TSIFYPVEVF ESSLSDPGPG KQDDSGQDVP LRVPGVVPVF DAHNLSVGSD YYIQLEEKSG SNLELDYPPA LLTTDMDNPE RTGPELSQLT ALRSVELEES STDEDFFQSS TDPKDSSLPG DLHVTSGPES PFNNIFNDVD KSEDLPSHQK IFDLMELNGV QADFKPATLS SSLDNPKESV ITGHFEKEKP RKIFDSEPLC LSDNLMHQDN FDPLNVQELS ENFLFLQEKN LLKGSLSSKE HINDLQTELK NAGFTEAMLE TSCRNSLDTE LQFAENKPGL SLLQENVSTK GDDTDVMLTG DTLSTSLQSS PEVQVPPTSF ETEETPRRVP PDSLPTQGET QPTCLDVIVP EDCLHQDISP DAVTVPVEIL STDARTHSLD NRSQDSPGES EETLRLTESD SVLADDILAS RVSVGSSLPE LGQELHNKPF SEDHHSHRRL EKNLEAVETL NQLNSKDAAK EAGLVSALSS DSTSQDSLLE DSLSAPFPAS EPSLETPDSL ESVDVHEALL DSLGSHTPQK LVPPDKPADS GYETENLESP EWTLHPAPEG TADSEPATTG DGGHSGLPPN PVIVISDAGD GHRGTEVTPE TFTAGSQGSY RDSAYFSDND SEPEKRSEEV PGTSPSALVL VQEQPLPEPV LPEQSPAAQD SCLEARKSQP DESCLSALHN SSDLELRATP EPAQTGVPQQ VHPTEDEASS PWSVLNAELS SGDDFETQDD RPCTLASTGT NTNELLAYTN SALDKSLSSH SEGPKLKEPD IEGKYLGKLG VSGMLDLSED GMDADEEDEN SDDSDEDLRA FNLHSLSSES EDETEHPVPI ILSNEDGRHL RSLLKPTAAN APDPLPEDWK KEKKAVTFFD DVTVYLFDQE TPTKELGPCG GEACGPDLSG PAPASGSPYL SRCINSESST DEEGGGFEWD DDFSPDPFMS KTTSNLLSSK PSLQTSKYFS PPPPARSTEQ SWPHSAPYSR FSISPANIAS FSLTHLTDSD IEQGGSSEDG EKD