LMTK1_HUMAN » Serine/threonine-protein kinase LMTK1

LMTK1_HUMAN » Serine/threonine-protein kinase LMTK1
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Topology in Endosome membrane
Topologyendosome lumenal side
cytoplasmic side
LMTK1_HUMAN » Serine/threonine-protein kinase LMTK1 » Apoptosis-associated tyrosine kinase;AATYK; Brain apoptosis-associated tyrosine kinase;CDK5-binding protein;Lemur tyrosine kinase 1;p35-binding protein;p35BP;
Hydrophobic Thickness 34.4 ± 2.2 Å
Tilt Angle 1 ± 0°
ΔGtransfer -40.6 kcal/mol
ΔGfold -18.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 31-53 (28-57)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ATD3A, Complex: ATD3A:LMTK1

SSRD, Complex: SSRD:LMTK1

Domains

AA: 125-395, PDBID: 1XBA, Subunit A, Seq Identity:36%, Protein tyrosine kinase

UniProt annotation for LMTK1_HUMAN » Serine/threonine-protein kinase LMTK1
FUNCTION: May be involved in neuronal differentiation.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

SUBUNIT: Interacts with CDK5.

TISSUE SPECIFICITY: Expressed in brain.

INDUCTION: Up-regulated during apoptosis.

UniProt features for LMTK1_HUMAN » Serine/threonine-protein kinase LMTK1
CHAIN 1 1374 Serine/threonine-protein kinase LMTK1.
DOMAIN 125 395 Protein kinase.
ACT_SITE 253 253 Proton acceptor (By similarity).
Amino Acid Sequence for LMTK1_HUMAN » Serine/threonine-protein kinase LMTK1
MSSSFFNPSF AFSSHFDPDG APLSELSWPS SLAVVAVSFS GLFAVIVLML ACLCCKKGGI GFKEFENAEG DEYAADLAQG SPATAAQNGP DVYVLPLTEV SLPMAKQPGR SVQLLKSTDV GRHSLLYLKE IGRGWFGKVF LGEVNSGISS AQVVVKELQA SASVQEQMQF LEEVQPYRAL KHSNLLQCLA QCAEVTPYLL VMEFCPLGDL KGYLRSCRVA ESMAPDPRTL QRMACEVACG VLHLHRNNFV HSDLALRNCL LTADLTVKIG DYGLAHCKYR EDYFVTADQL WVPLRWIAPE LVDEVHSNLL VVDQTKSGNV WSLGVTIWEL FELGTQPYPQ HSDQQVLAYT VREQQLKLPK PQLQLTLSDR WYEVMQFCWL QPEQRPTAEE VHLLLSYLCA KGATEAEEEF ERRWRSLRPG GGGVGPGPGA AGPMLGGVVE LAAASSFPLL EQFAGDGFHA DGDDVLTVTE TSRGLNFEYK WEAGRGAEAF PATLSPGRTA RLQELCAPDG APPGVVPVLS AHSPSLGSEY FIRLEEAAPA AGHDPDCAGC APSPPATADQ DDDSDGSTAA SLAMEPLLGH GPPVDVPWGR GDHYPRRSLA RDPLCPSRSP SPSAGPLSLA EGGAEDADWG VAAFCPAFFE DPLGTSPLGS SGAPPLPLTG EDELEEVGAR RAAQRGHWRS NVSANNNSGS RCPESWDPVS AGGHAEGCPS PKQTPRASPE PGYPGEPLLG LQAASAQEPG CCPGLPHLCS AQGLAPAPCL VTPSWTETAS SGGDHPQAEP KLATEAEGTT GPRLPLPSVP SPSQEGAPLP SEEASAPDAP DALPDSPTPA TGGEVSAIKL ASALNGSSSS PEVEAPSSED EDTAEATSGI FTDTSSDGLQ ARRPDVVPAF RSLQKQVGTP DSLDSLDIPS SASDGGYEVF SPSATGPSGG QPRALDSGYD TENYESPEFV LKEAQEGCEP QAFAELASEG EGPGPETRLS TSLSGLNEKN PYRDSAYFSD LEAEAEATSG PEKKCGGDRA PGPELGLPST GQPSEQVCLR PGVSGEAQGS GPGEVLPPLL QLEGSSPEPS TCPSGLVPEP PEPQGPAKVR PGPSPSCSQF FLLTPVPLRS EGNSSEFQGP PGLLSGPAPQ KRMGGPGTPR APLRLALPGL PAALEGRPEE EEEDSEDSDE SDEELRCYSV QEPSEDSEEE APAVPVVVAE SQSARNLRSL LKMPSLLSET FCEDLERKKK AVSFFDDVTV YLFDQESPTR ELGEPFPGAK ESPPTFLRGS PGSPSAPNRP QQADGSPNGS TAEEGGGFAW DDDFPLMTAK AAFAMALDPA APAPAAPTPT PAPFSRFTVS PAPTSRFSIT HVSDSDAESK RGPEAGAGGE SKEA