LMAN2_HUMAN » Vesicular integral-membrane protein VIP36

LMAN2_HUMAN » Vesicular integral-membrane protein VIP36
Magnify LMAN2_HUMAN » Vesicular integral-membrane protein VIP36Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
LMAN2_HUMAN » Vesicular integral-membrane protein VIP36 » Glycoprotein GP36b;Lectin mannose-binding 2;Vesicular integral-membrane protein 36;VIP36;
Hydrophobic Thickness 35.2 ± 1.8 Å
Tilt Angle 1 ± 0°
ΔGtransfer -46.3 kcal/mol
ΔGfold -23.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 320-346 (317-350)
Pathways

Protein processing in endoplasmic reticulum (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 52-278, PDBID: 2DUO, Subunit B, Seq Identity:99%, Legume-like lectin family

UniProt annotation for LMAN2_HUMAN » Vesicular integral-membrane protein VIP36
FUNCTION: Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).

TISSUE SPECIFICITY: Ubiquitous.

UniProt features for LMAN2_HUMAN » Vesicular integral-membrane protein VIP36
SIGNAL 1 44 Potential.
CHAIN 45 356 Vesicular integral-membrane protein VIP36.
DOMAIN 52 276 L-type lectin-like.
REGION 164 166 Carbohydrate binding (By similarity).
REGION 260 262 Carbohydrate binding (By similarity).
DISULFID 202 239 By similarity.
Amino Acid Sequence for LMAN2_HUMAN » Vesicular integral-membrane protein VIP36
MAAEGWIWRW GWGRRCLGRP GLLGPGPGPT TPLFLLLLLG SVTADITDGN SEHLKREHSL IKPYQGVGSS SMPLWDFQGS TMLTSQYVRL TPDERSKEGS IWNHQPCFLK DWEMHVHFKV HGTGKKNLHG DGIALWYTRD RLVPGPVFGS KDNFHGLAIF LDTYPNDETT ERVFPYISVM VNNGSLSYDH SKDGRWTELA GCTADFRNRD HDTFLAVRYS RGRLTVMTDL EDKNEWKNCI DITGVRLPTG YYFGASAGTG DLSDNHDIIS MKLFQLMVEH TPDEESIDWT KIEPSVNFLK SPKDNVDDPT GNFRSGPLTG WRVFLLLLCA LLGIVVCAVV GAVVFQKRQE RNKRFY