LMA2L_HUMAN » VIP36-like protein

LMA2L_HUMAN » VIP36-like protein
Magnify LMA2L_HUMAN » VIP36-like proteinEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
LMA2L_HUMAN » VIP36-like protein » Lectin mannose-binding 2-like;LMAN2-like protein;
Hydrophobic Thickness 30.4 ± 3.2 Å
Tilt Angle 49 ± 2°
ΔGtransfer -30.5 kcal/mol
ΔGfold -27.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 311-336 (311-344)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 49-276, PDBID: 2DUO, Subunit B, Seq Identity:68%, Legume-like lectin family

UniProt annotation for LMA2L_HUMAN » VIP36-like protein
FUNCTION: May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53.

TISSUE SPECIFICITY: Expressed in numerous tissues. Highest expression in skeletal muscle and kidney, intermediate levels in heart, liver and placenta, low levels in brain, thymus, spleen, small intestine and lung.

UniProt features for LMA2L_HUMAN » VIP36-like protein
SIGNAL 1 44 Potential.
CHAIN 45 348 VIP36-like protein.
DOMAIN 49 274 L-type lectin-like.
REGION 161 163 Carbohydrate binding (By similarity).
REGION 258 260 Carbohydrate binding (By similarity).
MOTIF 344 346 Endoplasmic reticulum retention signal.
DISULFID 200 237 By similarity.
Amino Acid Sequence for LMA2L_HUMAN » VIP36-like protein
MAATLGPLGS WQQWRRCLSA RDGSRMLLLL LLLGSGQGPQ QVGAGQTFEY LKREHSLSKP YQGVGTGSSS LWNLMGNAMV MTQYIRLTPD MQSKQGALWN RVPCFLRDWE LQVHFKIHGQ GKKNLHGDGL AIWYTKDRMQ PGPVFGNMDK FVGLGVFVDT YPNEEKQQER VFPYISAMVN NGSLSYDHER DGRPTELGGC TAIVRNLHYD TFLVIRYVKR HLTIMMDIDG KHEWRDCIEV PGVRLPRGYY FGTSSITGDL SDNHDVISLK LFELTVERTP EEEKLHRDVF LPSVDNMKLP EMTAPLPPLS GLALFLIVFF SLVFSVFAIV IGIILYNKWQ EQSRKRFY