LIRB5_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 5

LIRB5_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LIRB5_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 5 » CD85 antigen-like family member C;Leukocyte immunoglobulin-like receptor 8;LIR-8;
Hydrophobic Thickness 34.8 ± 3.4 Å
Tilt Angle 15 ± 9°
ΔGtransfer -29.2 kcal/mol
ΔGfold -23.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 458-482 (455-486)
Pathways

Immune System (Reactome)

Osteoclast differentiation (KEGG)

PDB none
OPM none
Complexes none
Interactions

CREB3, Complex: LIRB5:CREB3

Domains

AA: 28-117, PDBID: 3P2T, Subunit A, Seq Identity:69%, Immunoglobulin domain

AA: 227-306, PDBID: 4LL9, Subunit C, Seq Identity:42%, Immunoglobulin domain

AA: 327-409, PDBID: 4LL9, Subunit C, Seq Identity:63%, Immunoglobulin domain

UniProt annotation for LIRB5_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 5
FUNCTION: May act as receptor for class I MHC antigens.

TISSUE SPECIFICITY: Detected in a natural killer (NK) cells.

DOMAIN: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for LIRB5_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 5
SIGNAL 1 23 Potential.
CHAIN 24 590 Leukocyte immunoglobulin-like receptor subfamily B member 5.
DOMAIN 27 116 Ig-like C2-type 1.
DOMAIN 111 228 Ig-like C2-type 2.
DOMAIN 224 313 Ig-like C2-type 3.
DOMAIN 337 418 Ig-like C2-type 4.
MOTIF 552 557 ITIM motif 1.
MOTIF 582 587 ITIM motif 2.
DISULFID 49 98 By similarity.
DISULFID 144 195 By similarity.
DISULFID 244 295 Potential.
DISULFID 344 395 Potential.
Amino Acid Sequence for LIRB5_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 5
MTLTLSVLIC LGLSVGPRTC VQAGTLPKPT LWAEPASVIA RGKPVTLWCQ GPLETEEYRL DKEGLPWARK RQNPLEPGAK AKFHIPSTVY DSAGRYRCYY ETPAGWSEPS DPLELVATGF YAEPTLLALP SPVVASGGNV TLQCDTLDGL LTFVLVEEEQ KLPRTLYSQK LPKGPSQALF PVGPVTPSCR WRFRCYYYYR KNPQVWSNPS DLLEILVPGV SRKPSLLIPQ GSVVARGGSL TLQCRSDVGY DIFVLYKEGE HDLVQGSGQQ PQAGLSQANF TLGPVSRSHG GQYRCYGAHN LSPRWSAPSD PLDILIAGLI PDIPALSVQP GPKVASGENV TLLCQSWHQI DTFFLTKEGA AHPPLCLKSK YQSYRHQAEF SMSPVTSAQG GTYRCYSAIR SYPYLLSSPS YPQELVVSGP SGDPSLSPTG STPTPGPEDQ PLTPTGLDPQ SGLGRHLGVV TGVSVAFVLL LFLLLFLLLR HRHQSKHRTS AHFYRPAGAA GPEPKDQGLQ KRASPVADIQ EEILNAAVKD TQPKDGVEMD ARAAASEAPQ DVTYAQLHSL TLRREATEPP PSQEREPPAE PSIYAPLAIH