LIRB4_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 4

LIRB4_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 4
Magnify LIRB4_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 4Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LIRB4_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 4 » CD85 antigen-like family member K;Immunoglobulin-like transcript 3;ILT-3; Leukocyte immunoglobulin-like receptor 5;LIR-5; Monocyte inhibitory receptor HM18;
Hydrophobic Thickness 36.4 ± 3.4 Å
Tilt Angle 1 ± 4°
ΔGtransfer -27.5 kcal/mol
ΔGfold -23.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 258-282 (258-287)
Pathways

Immune System (Reactome)

Osteoclast differentiation (KEGG)

PDB 3p2t (A=24-219)
OPM 3p2t
Complexes none
Interactions none
Domains

AA: 28-117, PDBID: 3P2T, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 127-209, PDBID: 3P2T, Subunit A, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for LIRB4_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 4
FUNCTION: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5- signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

SUBUNIT: Binds PTPN6 when phosphorylated.

TISSUE SPECIFICITY: Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.

INDUCTION: Upon contact with CD8(+)CD28(-) alloantigen-specific T suppressor (Ts) cells.

DOMAIN: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for LIRB4_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 4
SIGNAL 1 21 Potential.
CHAIN 22 448 Leukocyte immunoglobulin-like receptor subfamily B member 4.
DOMAIN 27 118 Ig-like C2-type 1.
DOMAIN 124 218 Ig-like C2-type 2.
MOTIF 358 363 ITIM motif 1.
MOTIF 410 415 ITIM motif 2.
MOTIF 440 445 ITIM motif 3.
DISULFID 49 98 By similarity.
DISULFID 144 195 By similarity.
Amino Acid Sequence for LIRB4_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 4
MIPTFTALLC LGLSLGPRTH MQAGPLPKPT LWAEPGSVIS WGNSVTIWCQ GTLEAREYRL DKEESPAPWD RQNPLEPKNK ARFSIPSMTE DYAGRYRCYY RSPVGWSQPS DPLELVMTGA YSKPTLSALP SPLVTSGKSV TLLCQSRSPM DTFLLIKERA AHPLLHLRSE HGAQQHQAEF PMSPVTSVHG GTYRCFSSHG FSHYLLSHPS DPLELIVSGS LEGPRPSPTR SVSTAAGPED QPLMPTGSVP HSGLRRHWEV LIGVLVVSIL LLSLLLFLLL QHWRQGKHRT LAQRQADFQR PPGAAEPEPK DGGLQRRSSP AADVQGENFC AAVKNTQPED GVEMDTRQSP HDEDPQAVTY AKVKHSRPRR EMASPPSPLS GEFLDTKDRQ AEEDRQMDTE AAASEAPQDV TYAQLHSFTL RQKATEPPPS QEGASPAEPS VYATLAIH