LIRB3_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 3

LIRB3_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 3
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Topology in Plasma membrane
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cytoplasmic side
LIRB3_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 3 » LIR-3; Leukocyte immunoglobulin-like receptor 3; CD85 antigen-like family member A;Immunoglobulin-like transcript 5;ILT-5; Monocyte inhibitory receptor HL9;
Hydrophobic Thickness 30.4 ± 1.4 Å
Tilt Angle 4 ± 1°
ΔGtransfer -42.6 kcal/mol
ΔGfold -25.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 441-465 (440-470)
Pathways

B cell receptor signaling pathway (KEGG)

Immune System (Reactome)

Osteoclast differentiation (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 28-117, PDBID: 2D3V, Subunit A, Seq Identity:63%, Immunoglobulin domain

AA: 324-418, PDBID: 2GI7, Subunit A, Seq Identity:47%, Immunoglobulin domain

UniProt annotation for LIRB3_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 3
FUNCTION: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B- cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM) (By similarity).

SUBUNIT: Interacts with LYN, PTPN6/SHP-1 and PTPN11/SHP-2.

TISSUE SPECIFICITY: Detected in monocytes and B-cells.

DOMAIN: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases, including PTPN6/SHP-1, resulting in the dephosphorylation of the downstream protein kinases SYK and BTK (By similarity).

MISCELLANEOUS: Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

UniProt features for LIRB3_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 3
SIGNAL 1 23 Potential.
CHAIN 24 631 Leukocyte immunoglobulin-like receptor subfamily B member 3.
DOMAIN 42 100 Ig-like C2-type 1.
DOMAIN 111 229 Ig-like C2-type 2.
DOMAIN 225 314 Ig-like C2-type 3.
DOMAIN 338 419 Ig-like C2-type 4.
MOTIF 512 517 ITIM motif 1.
MOTIF 593 598 ITIM motif 2.
MOTIF 623 628 ITIM motif 3.
DISULFID 49 98 By similarity.
DISULFID 144 196 By similarity.
DISULFID 245 296 Potential.
DISULFID 345 396 Potential.
Amino Acid Sequence for LIRB3_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 3
MTPALTALLC LGLSLGPRTR VQAGPFPKPT LWAEPGSVIS WGSPVTIWCQ GSLEAQEYQL DKEGSPEPLD RNNPLEPKNK ARFSIPSMTQ HHAGRYRCHY YSSAGWSEPS DPLELVMTGA YSKPTLSALP SPVVASGGNM TLRCGSQKRY HHFVLMKEGE HQLPRTLDSQ QLHSGGFQAL FPVGPVNPSH RWRFTCYYYY MNTPRVWSHP SDPLEILPSG VSRKPSLLTL QGPVLAPGQS LTLQCGSDVG YDRFVLYKEG ERDFLQRPGQ QPQAGLSQAN FTLGPVSPSN GGQYRCYGAH NLSSEWSAPS DPLNILMAGQ IYDTVSLSAQ PGPTVASGEN VTLLCQSWWQ FDTFLLTKEG AAHPPLRLRS MYGAHKYQAE FPMSPVTSAH AGTYRCYGSY SSNPYLLSHP SEPLELVVSG HSGGSSLPPT GPPSTPGLGR YLEVLIGVSV AFVLLLFLLL FLLLRRQRHS KHRTSDQRKT DFQRPAGAAE TEPKDRGLLR RSSPAADVQE ENLYAAVKDT QSEDGVELDS QSPHDEDPHA VTYAPVKHSS PRREMASPPS PLSGEFLDTK DRQAEEDRQM DTEAAASEAS QDVTYAQLHS LTLRRKATEP PPSQEGEPPA EPSIYATLAI H