LIRB2_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 2

LIRB2_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 2
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Topology in Plasma membrane
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LIRB2_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 2 » LIR-2; Leukocyte immunoglobulin-like receptor 2; CD85 antigen-like family member D;Immunoglobulin-like transcript 4;ILT-4; Monocyte/macrophage immunoglobulin-like receptor 10;MIR-10;
Hydrophobic Thickness 35.6 ± 1.4 Å
Tilt Angle 0 ± 2°
ΔGtransfer -65.1 kcal/mol
ΔGfold -33.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 459-484 (457-487)
Pathways

Immune System (Reactome)

Osteoclast differentiation (KEGG)

PDB 4lla (222-419), 2gw5 (24-219), 2dyp (D=24-219)
OPM none
Complexes

LIRB2:HLAG:H2AX:B2MG_HUMAN

Interactions

1B07, Complex: 1B07:LIRB2, PubMed

CD1D, Complex: LIRB2:CD1D, PubMed

FCGR1, Complex: FCGR1:LIRB2, PubMed

HLAF, Complex: HLAF:LIRB2, PubMed

HLAG, Complex: B2MG:HLAG:LIRB2, PDBID: 2dyp

HLAG, Complex: LIRB2:HLAG, PubMed

Domains

AA: 28-117, PDBID: 2DYP, Subunit D, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for LIRB2_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 2
FUNCTION: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

SUBUNIT: Binds PTPN6 when phosphorylated. Binds FCGR1A.

TISSUE SPECIFICITY: Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells.

DOMAIN: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for LIRB2_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 2
SIGNAL 1 21 Potential.
CHAIN 22 598 Leukocyte immunoglobulin-like receptor subfamily B member 2.
DOMAIN 27 110 Ig-like C2-type 1.
DOMAIN 111 229 Ig-like C2-type 2.
DOMAIN 230 318 Ig-like C2-type 3.
DOMAIN 330 419 Ig-like C2-type 4.
MOTIF 531 536 ITIM motif 1.
MOTIF 560 565 ITIM motif 2.
MOTIF 590 595 ITIM motif 3.
DISULFID 49 98 By similarity.
DISULFID 144 196 By similarity.
DISULFID 156 166 By similarity.
DISULFID 245 296 Potential.
DISULFID 345 396 Potential.
Amino Acid Sequence for LIRB2_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 2
MTPIVTVLIC LGLSLGPRTH VQTGTIPKPT LWAEPDSVIT QGSPVTLSCQ GSLEAQEYRL YREKKSASWI TRIRPELVKN GQFHIPSITW EHTGRYGCQY YSRARWSELS DPLVLVMTGA YPKPTLSAQP SPVVTSGGRV TLQCESQVAF GGFILCKEGE DEHPQCLNSQ PHARGSSRAI FSVGPVSPNR RWSHRCYGYD LNSPYVWSSP SDLLELLVPG VSKKPSLSVQ PGPVVAPGES LTLQCVSDVG YDRFVLYKEG ERDLRQLPGR QPQAGLSQAN FTLGPVSRSY GGQYRCYGAY NLSSEWSAPS DPLDILITGQ IRGTPFISVQ PGPTVASGEN VTLLCQSWRQ FHTFLLTKAG AADAPLRLRS IHEYPKYQAE FPMSPVTSAH AGTYRCYGSL NSDPYLLSHP SEPLELVVSG PSMGSSPPPT GPISTPAGPE DQPLTPTGSD PQSGLGRHLG VVIGILVAVV LLLLLLLLLF LILRHRRQGK HWTSTQRKAD FQHPAGAVGP EPTDRGLQWR SSPAADAQEE NLYAAVKDTQ PEDGVEMDTR AAASEAPQDV TYAQLHSLTL RRKATEPPPS QEREPPAEPS IYATLAIH