LIRB1_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 1

LIRB1_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LIRB1_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 1 » LIR-1; Leukocyte immunoglobulin-like receptor 1; CD85 antigen-like family member J;Immunoglobulin-like transcript 2;ILT-2; Monocyte/macrophage immunoglobulin-like receptor 7;MIR-7;
Hydrophobic Thickness 36.4 ± 1.6 Å
Tilt Angle 0 ± 3°
ΔGtransfer -65.3 kcal/mol
ΔGfold -33.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 459-484 (457-487)
Pathways

Immune System (Reactome)

Osteoclast differentiation (KEGG)

PDB 4ll9 (222-417), 1ugn (24-221), 1g0x (25-221), 1ufu (25-221), 1vdg (A/B=24-220), 3d2u (D/H=24-221), 1p7q (D=25-221), 4no0 (D=27-221)
OPM none
Complexes

LIRB1:LSP1:1A02:B2MG_HUMAN

POL:LIRB1:1A02:B2MG_HUMAN

LIRB1:LIRB1_HUMAN

Interactions

1A02, Complex: 1A02:B2MG:LIRB1, PDBID: 1p7q

1B07, Complex: LIRB1:1B07, PubMed

1C07, Complex: 1C07:LIRB1

HLAF, Complex: LIRB1:HLAF, PubMed

HLAG, Complex: HLAG:LIRB1, PubMed

LIRB1, Complex: Homodimer of leukocyte immunoglobulin-like receptor B1, PDBID: 1VDG

Domains

AA: 28-118, PDBID: 1G0X, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 329-410, PDBID: 4LL9, Subunit C, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for LIRB1_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 1
FUNCTION: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

SUBUNIT: Binds PTPN6 when phosphorylated. Binds FCER1A and FCGR1A. Interacts with human cytomegalovirus/HHV-5 protein UL18.

TISSUE SPECIFICITY: Expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells. Detected on a low percentage of T-cells and natural killer (NK) cells.

DOMAIN: Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for LIRB1_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 1
SIGNAL 1 23 Potential.
CHAIN 24 650 Leukocyte immunoglobulin-like receptor subfamily B member 1.
DOMAIN 27 115 Ig-like C2-type 1.
DOMAIN 116 221 Ig-like C2-type 2.
DOMAIN 222 312 Ig-like C2-type 3.
DOMAIN 313 409 Ig-like C2-type 4.
MOTIF 531 536 ITIM motif 1.
MOTIF 560 565 ITIM motif 2.
MOTIF 612 617 ITIM motif 3.
MOTIF 642 647 ITIM motif 4.
DISULFID 49 98
DISULFID 145 197
DISULFID 157 167
DISULFID 246 297 Potential.
DISULFID 346 397 Potential.
Amino Acid Sequence for LIRB1_HUMAN » Leukocyte immunoglobulin-like receptor subfamily B member 1
MTPILTVLIC LGLSLGPRTH VQAGHLPKPT LWAEPGSVIT QGSPVTLRCQ GGQETQEYRL YREKKTALWI TRIPQELVKK GQFPIPSITW EHAGRYRCYY GSDTAGRSES SDPLELVVTG AYIKPTLSAQ PSPVVNSGGN VILQCDSQVA FDGFSLCKEG EDEHPQCLNS QPHARGSSRA IFSVGPVSPS RRWWYRCYAY DSNSPYEWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPEE TLTLQCGSDA GYNRFVLYKD GERDFLQLAG AQPQAGLSQA NFTLGPVSRS YGGQYRCYGA HNLSSEWSAP SDPLDILIAG QFYDRVSLSV QPGPTVASGE NVTLLCQSQG WMQTFLLTKE GAADDPWRLR STYQSQKYQA EFPMGPVTSA HAGTYRCYGS QSSKPYLLTH PSDPLELVVS GPSGGPSSPT TGPTSTSGPE DQPLTPTGSD PQSGLGRHLG VVIGILVAVI LLLLLLLLLF LILRHRRQGK HWTSTQRKAD FQHPAGAVGP EPTDRGLQWR SSPAADAQEE NLYAAVKHTQ PEDGVEMDTR SPHDEDPQAV TYAEVKHSRP RREMASPPSP LSGEFLDTKD RQAEEDRQMD TEAAASEAPQ DVTYAQLHSL TLRREATEPP PSQEGPSPAV PSIYATLAIH