LIRA6_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 6

LIRA6_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 6
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LIRA6_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 6 » Immunoglobulin-like transcript 8;ILT-8; Leukocyte Ig-like receptor;
Hydrophobic Thickness 33.8 ± 2.2 Å
Tilt Angle 4 ± 5°
ΔGtransfer -21.5 kcal/mol
ΔGfold -14.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 447-469 (445-472)
Pathways

Osteoclast differentiation (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 28-117, PDBID: 2D3V, Subunit A, Seq Identity:65%, Immunoglobulin domain

AA: 328-411, PDBID: 4LL9, Subunit C, Seq Identity:69%, Immunoglobulin domain

UniProt annotation for LIRA6_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 6
FUNCTION: May act as receptor for class I MHC antigens.

MISCELLANEOUS: Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

UniProt features for LIRA6_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 6
SIGNAL 1 23 Potential.
CHAIN 24 481 Leukocyte immunoglobulin-like receptor subfamily A member 6.
DOMAIN 225 314 Ig-like C2-type 1.
DOMAIN 323 408 Ig-like C2-type 2.
DISULFID 245 296 By similarity.
DISULFID 345 396 By similarity.
Amino Acid Sequence for LIRA6_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 6
MTPALTALLC LGLSLGPRTR VQAGPFPKPT LWAEPGSVIS WGSPVTIWCQ GSLEAQEYQL DKEGSPEPLD RNNPLEPKNK ARFSIPSMTQ HHAGRYRCHY YSSAGWSEPS DPLELVMTGF YNKPTLSALP SPVVASGGNM TLRCGSQKGY HHFVLMKEGE HQLPRTLDSQ QLHSGGFQAL FPVGPVTPSH RWRFTCYYYY TNTPRVWSHP SDPLEILPSG VSRKPSLLTL QGPVLAPGQS LTLQCGSDVG YDRFVLYKEG ERDFLQRPGQ QPQAGLSQAN FTLGPVSPSH GGQYRCYGAH NLSSEWSAPS DPLNILMAGQ IYDTVSLSAQ PGPTVASGEN VTLLCQSRGY FDTFLLTKEG AAHPPLRLRS MYGAHKYQAE FPMSPVTSAH AGTYRCYGSY SSNPHLLSFP SEPLELMVSG HSGGSSLPPT GPPSTPASHA KDYTVENLIR MGMAGLVLVF LGILLFEAQH SQRNPQDAAG R