LIRA5_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 5

LIRA5_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 5
Magnify LIRA5_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 5Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LIRA5_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 5 » CD85 antigen-like family member F;Immunoglobulin-like transcript 11;ILT-11; Leukocyte immunoglobulin-like receptor 9;LIR-9;
Hydrophobic Thickness 29.2 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -33.8 kcal/mol
ΔGfold -14.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 262-287 (262-292)
Pathways

Osteoclast differentiation (KEGG)

PDB 2d3v (42-237)
OPM none
Complexes none
Interactions none
Domains

AA: 46-135, PDBID: 2D3V, Subunit A, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for LIRA5_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 5
FUNCTION: May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.

TISSUE SPECIFICITY: Expressed mostly in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed in CD14+ monocytes, but not in T-cells, B-cells or natural killer (NK) cells (at protein level).

UniProt features for LIRA5_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 5
SIGNAL 1 41 Potential.
CHAIN 42 299 Leukocyte immunoglobulin-like receptor subfamily A member 5.
DOMAIN 51 136 Ig-like C2-type 1.
DOMAIN 142 230 Ig-like C2-type 2.
DISULFID 67 116 By similarity.
DISULFID 162 214 By similarity.
Amino Acid Sequence for LIRA5_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 5
MAPWSHPSAQ LQPVGGDAVS PALMVLLCLG LSLGPRTHVQ AGNLSKATLW AEPGSVISRG NSVTIRCQGT LEAQEYRLVK EGSPEPWDTQ NPLEPKNKAR FSIPSMTEHH AGRYRCYYYS PAGWSEPSDP LELVVTGFYN KPTLSALPSP VVTSGENVTL QCGSRLRFDR FILTEEGDHK LSWTLDSQLT PSGQFQALFP VGPVTPSHRW MLRCYGSRRH ILQVWSEPSD LLEIPVSGAA DNLSPSQNKS DSGTASHLQD YAVENLIRMG MAGLILVVLG ILIFQDWHSQ RSPQAAAGR