LIRA4_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 4

LIRA4_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LIRA4_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 4 » CD85 antigen-like family member G;Immunoglobulin-like transcript 7;ILT-7;
Hydrophobic Thickness 33.6 ± 2.1 Å
Tilt Angle 7 ± 6°
ΔGtransfer -22.1 kcal/mol
ΔGfold -14.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 446-468 (444-471)
Pathways

Osteoclast differentiation (KEGG)

PDB none
OPM none
Complexes none
Interactions

BST2, Complex: BST2:LIRA4, PubMed

Domains

AA: 28-117, PDBID: 3P2T, Subunit A, Seq Identity:57%, Immunoglobulin domain

AA: 126-210, PDBID: 3H8N, Subunit A, Seq Identity:45%, Immunoglobulin domain

AA: 323-417, PDBID: 2GI7, Subunit A, Seq Identity:47%, Immunoglobulin domain

UniProt annotation for LIRA4_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 4
FUNCTION: May act as receptor for class I MHC antigens. Ligand binding leads to the activation of eosinophils and to the release of RNASE2, IL4 and leukotriene C4.

SUBUNIT: Interacts with BST2.

TISSUE SPECIFICITY: Detected in eosinophils, neutrophils and monocytes.

UniProt features for LIRA4_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 4
SIGNAL 1 23 Potential.
CHAIN 24 499 Leukocyte immunoglobulin-like receptor subfamily A member 4.
DOMAIN 24 118 Ig-like C2-type 1.
DOMAIN 123 213 Ig-like C2-type 2.
DOMAIN 224 313 Ig-like C2-type 3.
DOMAIN 324 413 Ig-like C2-type 4.
DISULFID 49 98 By similarity.
DISULFID 143 195 By similarity.
DISULFID 244 295 Potential.
DISULFID 344 395 Potential.
Amino Acid Sequence for LIRA4_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 4
MTPILTVLIC LGLSLGPRTR VQAENLPKPI LWAEPGPVIT WHNPVTIWCQ GTLEAQGYRL DKEGNSMSRH ILKTLESENK VKLSIPSMMW EHAGRYHCYY QSPAGWSEPS DPLELVVTAY SRPTLSALPS PVVTSGVNVT LRCASRLGLG RFTLIEEGDH RLSWTLNSHQ HNHGKFQALF PMGPLTFSNR GTFRCYGYEN NTPYVWSEPS DPLQLLVSGV SRKPSLLTLQ GPVVTPGENL TLQCGSDVGY IRYTLYKEGA DGLPQRPGRQ PQAGLSQANF TLSPVSRSYG GQYRCYGAHN VSSEWSAPSD PLDILIAGQI SDRPSLSVQP GPTVTSGEKV TLLCQSWDPM FTFLLTKEGA AHPPLRLRSM YGAHKYQAEF PMSPVTSAHA GTYRCYGTRS SNPYLLSHPS EPLELVVSGA TETLNPAQKK SDSKTAPHLQ DYTVENLIRM GVAGLVLLFL GILLFEAQHS QRSPPRCSQE ANSRKDNAPF RVVEPWEQI