LIRA2_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 2

LIRA2_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LIRA2_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 2 » CD85 antigen-like family member H;Immunoglobulin-like transcript 1;ILT-1; Leukocyte immunoglobulin-like receptor 7;LIR-7;
Hydrophobic Thickness 27.2 ± 2.4 Å
Tilt Angle 7 ± 2°
ΔGtransfer -31.8 kcal/mol
ΔGfold -13.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 449-471 (447-474)
Pathways

Osteoclast differentiation (KEGG)

PDB 2otp (A/B=24-219)
OPM none
Complexes

LIRA2:LIRA2_HUMAN

Interactions

LIRA2, Complex: Homodimer of leukocyte immunoglobulin-like receptor A2, PDBID: 2OTP

Domains

AA: 28-116, PDBID: 2OTP, Subunit B, Seq Identity:100%, Immunoglobulin domain

AA: 327-409, PDBID: 4LL9, Subunit C, Seq Identity:73%, Immunoglobulin domain

UniProt annotation for LIRA2_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 2
FUNCTION: Does not bind class I MHC antigens.

SUBUNIT: Homodimer.

TISSUE SPECIFICITY: Expression levels are very low or not detectable on monocytes, T-cells, B-cells, dendritic cells and natural killer (NK) cells.

UniProt features for LIRA2_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 2
SIGNAL 1 23 Potential.
CHAIN 24 483 Leukocyte immunoglobulin-like receptor subfamily A member 2.
DOMAIN 27 113 Ig-like C2-type 1.
DOMAIN 117 222 Ig-like C2-type 2.
DOMAIN 224 313 Ig-like C2-type 3.
DOMAIN 324 413 Ig-like C2-type 4.
DISULFID 49 97
DISULFID 143 195
DISULFID 244 295 Potential.
DISULFID 344 395 Potential.
Amino Acid Sequence for LIRA2_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 2
MTPILTVLIC LGLSLGPRTH VQAGHLPKPT LWAEPGSVII QGSPVTLRCQ GSLQAEEYHL YRENKSASWV RRIQEPGKNG QFPIPSITWE HAGRYHCQYY SHNHSSEYSD PLELVVTGAY SKPTLSALPS PVVTLGGNVT LQCVSQVAFD GFILCKEGED EHPQRLNSHS HARGWSWAIF SVGPVSPSRR WSYRCYAYDS NSPYVWSLPS DLLELLVPGV SKKPSLSVQP GPMVAPGESL TLQCVSDVGY DRFVLYKEGE RDFLQRPGWQ PQAGLSQANF TLGPVSPSHG GQYRCYSAHN LSSEWSAPSD PLDILITGQF YDRPSLSVQP VPTVAPGKNV TLLCQSRGQF HTFLLTKEGA GHPPLHLRSE HQAQQNQAEF RMGPVTSAHV GTYRCYSSLS SNPYLLSLPS DPLELVVSEA AETLSPSQNK TDSTTTSLGQ HPQDYTVENL IRMGVAGLVL VVLGILLFEA QHSQRSLQDA AGR