LIRA1_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 1

LIRA1_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LIRA1_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 1 » CD85 antigen-like family member I;Leukocyte immunoglobulin-like receptor 6;LIR-6;
Hydrophobic Thickness 33.6 ± 2.2 Å
Tilt Angle 6 ± 5°
ΔGtransfer -21.1 kcal/mol
ΔGfold -14.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 461-483 (459-486)
Pathways

Immune System (Reactome)

Osteoclast differentiation (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 28-118, PDBID: 1G0X, Subunit A, Seq Identity:73%, Immunoglobulin domain

AA: 325-419, PDBID: 2GI7, Subunit A, Seq Identity:45%, Immunoglobulin domain

UniProt annotation for LIRA1_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 1
FUNCTION: May act as receptor for class I MHC antigens.

TISSUE SPECIFICITY: Detected in monocytes and B-cells.

UniProt features for LIRA1_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 1
SIGNAL 1 16 Potential.
CHAIN 17 489 Leukocyte immunoglobulin-like receptor subfamily A member 1.
DOMAIN 27 116 Ig-like C2-type 1.
DOMAIN 119 224 Ig-like C2-type 2.
DOMAIN 226 315 Ig-like C2-type 3.
DOMAIN 326 415 Ig-like C2-type 4.
DISULFID 49 98 By similarity.
DISULFID 145 197 By similarity.
DISULFID 157 167 By similarity.
DISULFID 246 297 Potential.
DISULFID 346 397 Potential.
Amino Acid Sequence for LIRA1_HUMAN » Leukocyte immunoglobulin-like receptor subfamily A member 1
MTPIVTVLIC LRLSLGPRTH VQAGTLPKPT LWAEPGSVIT QGSPVTLWCQ GILETQEYRL YREKKTAPWI TRIPQEIVKK GQFPIPSITW EHTGRYRCFY GSHTAGWSEP SDPLELVVTG AYIKPTLSAL PSPVVTSGGN VTLHCVSQVA FGSFILCKEG EDEHPQCLNS QPRTHGWSRA IFSVGPVSPS RRWSYRCYAY DSNSPHVWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPGE SLTLQCVSDV SYDRFVLYKE GERDFLQLPG PQPQAGLSQA NFTLGPVSRS YGGQYRCSGA YNLSSEWSAP SDPLDILIAG QFRGRPFISV HPGPTVASGE NVTLLCQSWG PFHTFLLTKA GAADAPLRLR SIHEYPKYQA EFPMSPVTSA HSGTYRCYGS LSSNPYLLSH PSDSLELMVS GAAETLSPPQ NKSDSKAGAA NTLSPSQNKT ASHPQDYTVE NLIRMGIAGL VLVVLGILLF EAQHSQRSL