LIME1_HUMAN » Lck-interacting transmembrane adapter 1

LIME1_HUMAN » Lck-interacting transmembrane adapter 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LIME1_HUMAN » Lck-interacting transmembrane adapter 1 » Lck-interacting membrane protein; Lck-interacting molecule;
Hydrophobic Thickness 32.0 ± 1.4 Å
Tilt Angle 25 ± 5°
ΔGtransfer -16.9 kcal/mol
ΔGfold -10.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 10-31 (10-33)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 27-259, Lck-interacting transmembrane adapter 1

UniProt annotation for LIME1_HUMAN » Lck-interacting transmembrane adapter 1
FUNCTION: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.

SUBUNIT: When phosphorylated in response to BCR activation, interacts with LYN, PIK3R1, PLCG2, and GRB2 (By similarity). When phosphorylated in response to TCR stimulation and/or CD4 co- stimulation, interacts with LCK, CSK, FYN, PTPN11/SHP2, GRB2, PIK3R1 and GRAP2.

TISSUE SPECIFICITY: Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level).

UniProt features for LIME1_HUMAN » Lck-interacting transmembrane adapter 1
CHAIN 1 295 Lck-interacting transmembrane adapter 1.
REGION 145 148 Interaction with GRB2 (By similarity).
REGION 167 170 Interaction with CSK.
REGION 200 203 Interaction with CSK.
REGION 235 238 Interaction with LCK and PIK3R1 (By similarity).
REGION 254 257 Interaction with LCK, PLCG2 and PIK3R1 (By similarity).
Amino Acid Sequence for LIME1_HUMAN » Lck-interacting transmembrane adapter 1
MGLPVSWAPP ALWVLGCCAL LLSLWALCTA CRRPEDAVAP RKRARRQRAR LQGSATAAEA SLLRRTHLCS LSKSDTRLHE LHRGPRSSRA LRPASMDLLR PHWLEVSRDI TGPQAAPSAF PHQELPRALP AAAATAGCAG LEATYSNVGL AALPGVSLAA SPVVAEYARV QKRKGTHRSP QEPQQGKTEV TPAAQVDVLY SRVCKPKRRD PGPTTDPLDP KGQGAILALA GDLAYQTLPL RALDVDSGPL ENVYESIREL GDPAGRSSTC GAGTPPASSC PSLGRGWRPL PASLP