LIGO1_HUMAN » Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

LIGO1_HUMAN » Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
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Topology in Plasma membrane
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LIGO1_HUMAN » Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 » Leucine-rich repeat and immunoglobilin domain-containing protein 1;Leucine-rich repeat neuronal protein 1;Leucine-rich repeat neuronal protein 6A;
Hydrophobic Thickness 42.4 ± 0.6 Å
Tilt Angle 4 ± 2°
ΔGtransfer -59.7 kcal/mol
ΔGfold -26.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 551-583 (551-586)
Pathways

Signal Transduction (Reactome)

PDB 2id5 (A/B/C/D=40-516), 4oqt (A=40-517)
OPM none
Complexes

LIGO1:LIGO1_HUMAN

Interactions

LIGO1, Complex: Homotetramer of LLR and Ig domain NOGO receptor-interacting protein 1, PDBID: 2ID5

NTRK2, Complex: LIGO1:NTRK2, PubMed

TNR16, Complex: LIGO1:TNR16, PubMed

TNR19, Complex: TNR19:LIGO1, PubMed

Domains

AA: 71-131, PDBID: 2ID5, Subunit D, Seq Identity:100%, Leucine rich repeat

AA: 95-155, PDBID: 2ID5, Subunit D, Seq Identity:100%, Leucine rich repeat

AA: 119-179, PDBID: 2ID5, Subunit D, Seq Identity:100%, Leucine rich repeat

AA: 143-203, PDBID: 2ID5, Subunit C, Seq Identity:100%, Leucine rich repeat

AA: 217-275, PDBID: 2ID5, Subunit D, Seq Identity:100%, Leucine rich repeat

AA: 312-371, PDBID: 2ID5, Subunit D, Seq Identity:100%, Leucine rich repeat

AA: 426-514, PDBID: 2ID5, Subunit D, Seq Identity:100%, Immunoglobulin I-set domain

UniProt annotation for LIGO1_HUMAN » Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
FUNCTION: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).

SUBUNIT: Homotetramer. Forms ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19.

TISSUE SPECIFICITY: Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.

UniProt features for LIGO1_HUMAN » Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
SIGNAL 1 41 Potential.
CHAIN 42 620 Leucine-rich repeat and immunoglobulin- like domain-containing nogo receptor- interacting protein 1.
DOMAIN 42 71 LRRNT.
REPEAT 72 93 LRR 1.
REPEAT 96 117 LRR 2.
REPEAT 120 141 LRR 3.
REPEAT 144 165 LRR 4.
REPEAT 168 189 LRR 5.
REPEAT 192 213 LRR 6.
REPEAT 216 237 LRR 7.
REPEAT 264 285 LRR 8.
REPEAT 288 309 LRR 9.
REPEAT 312 333 LRR 10.
REPEAT 336 357 LRR 11.
DOMAIN 369 423 LRRCT.
DOMAIN 411 513 Ig-like C2-type.
DISULFID 42 48
DISULFID 46 57
DISULFID 373 396
DISULFID 375 421
DISULFID 446 497
Amino Acid Sequence for LIGO1_HUMAN » Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
MQVSKRMLAG GVRSMPSPLL ACWQPILLLV LGSVLSGSAT GCPPRCECSA QDRAVLCHRK RFVAVPEGIP TETRLLDLGK NRIKTLNQDE FASFPHLEEL ELNENIVSAV EPGAFNNLFN LRTLGLRSNR LKLIPLGVFT GLSNLTKLDI SENKIVILLD YMFQDLYNLK SLEVGDNDLV YISHRAFSGL NSLEQLTLEK CNLTSIPTEA LSHLHGLIVL RLRHLNINAI RDYSFKRLYR LKVLEISHWP YLDTMTPNCL YGLNLTSLSI THCNLTAVPY LAVRHLVYLR FLNLSYNPIS TIEGSMLHEL LRLQEIQLVG GQLAVVEPYA FRGLNYLRVL NVSGNQLTTL EESVFHSVGN LETLILDSNP LACDCRLLWV FRRRWRLNFN RQQPTCATPE FVQGKEFKDF PDVLLPNYFT CRRARIRDRK AQQVFVDEGH TVQFVCRADG DPPPAILWLS PRKHLVSAKS NGRLTVFPDG TLEVRYAQVQ DNGTYLCIAA NAGGNDSMPA HLHVRSYSPD WPHQPNKTFA FISNQPGEGE ANSTRATVPF PFDIKTLIIA TTMGFISFLG VVLFCLVLLF LWSRGKGNTK HNIEIEYVPR KSDAGISSAD APRKFNMKMI