LFA3_HUMAN » Lymphocyte function-associated antigen 3

LFA3_HUMAN » Lymphocyte function-associated antigen 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LFA3_HUMAN » Lymphocyte function-associated antigen 3 » Ag3; Surface glycoprotein LFA-3;
Hydrophobic Thickness 34.4 ± 2.0 Å
Tilt Angle 1 ± 4°
ΔGtransfer -19.5 kcal/mol
ΔGfold -10.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 214-238 (212-243)
Pathways

Cell adhesion molecules (KEGG)

Epstein-Barr virus infection (KEGG)

Hemostasis (Reactome)

PDB 1ccz (29-122), 1ci5 (29-123), 1qa9 (B/D=30-123)
OPM none
Complexes

LFA3:CD2_HUMAN

Interactions

A4, Complex: LFA3:A4, PubMed

CD2, Complex: CD2:LFA3, PDBID: 1qa9, PubMed

Domains none
UniProt annotation for LFA3_HUMAN » Lymphocyte function-associated antigen 3
FUNCTION: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen- presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.

SUBUNIT: Interacts with CD2.

UniProt features for LFA3_HUMAN » Lymphocyte function-associated antigen 3
SIGNAL 1 28
CHAIN 29 250 Lymphocyte function-associated antigen 3.
DOMAIN 135 194 Ig-like C2-type.
DISULFID 142 187 By similarity.
Amino Acid Sequence for LFA3_HUMAN » Lymphocyte function-associated antigen 3
MVAGSDAGRA LGVLSVVCLL HCFGFISCFS QQIYGVVYGN VTFHVPSNVP LKEVLWKKQK DKVAELENSE FRAFSSFKNR VYLDTVSGSL TIYNLTSSDE DEYEMESPNI TDTMKFFLYV LESLPSPTLT CALTNGSIEV QCMIPEHYNS HRGLIMYSWD CPMEQCKRNS TSIYFKMEND LPQKIQCTLS NPLFNTTSSI ILTTCIPSSG HSRHRYALIP IPLAVITTCI VLYMNGILKC DRKPDRTNSN