LEUK_HUMAN » Leukosialin

LEUK_HUMAN » Leukosialin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LEUK_HUMAN » Leukosialin » Galactoglycoprotein;GALGP; Leukocyte sialoglycoprotein;Sialophorin;
Hydrophobic Thickness 34.8 ± 0.7 Å
Tilt Angle 12 ± 10°
ΔGtransfer -31.2 kcal/mol
ΔGfold -28.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 255-277 (255-283)
Pathways

Cell adhesion molecules (KEGG)

Epstein-Barr virus infection (KEGG)

Hemostasis (Reactome)

PDB none
OPM none
Complexes none
Interactions

ICAM1, Complex: LEUK:ICAM1, PubMed

INT1, Complex: LEUK:INT1, PubMed

SN, Complex: SN:LEUK, PubMed

Domains none
UniProt annotation for LEUK_HUMAN » Leukosialin
FUNCTION: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity).

SUBUNIT: Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX (By similarity).

TISSUE SPECIFICITY: Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.

UniProt features for LEUK_HUMAN » Leukosialin
SIGNAL 1 19
CHAIN 20 400 Leukosialin.
Amino Acid Sequence for LEUK_HUMAN » Leukosialin
MATLLLLLGV LVVSPDALGS TTAVQTPTSG EPLVSTSEPL SSKMYTTSIT SDPKADSTGD QTSALPPSTS INEGSPLWTS IGASTGSPLP EPTTYQEVSI KMSSVPQETP HATSHPAVPI TANSLGSHTV TGGTITTNSP ETSSRTSGAP VTTAASSLET SRGTSGPPLT MATVSLETSK GTSGPPVTMA TDSLETSTGT TGPPVTMTTG SLEPSSGASG PQVSSVKLST MMSPTTSTNA STVPFRNPDE NSRGMLPVAV LVALLAVIVL VALLLLWRRR QKRRTGALVL SRGGKRNGVV DAWAGPAQVP EEGAVTVTVG GSGGDKGSGF PDGEGSSRRP TLTTFFGRRK SRQGSLAMEE LKSGSGPSLK GEEEPLVASE DGAVDAPAPD EPEGGDGAAP