LECT1_HUMAN » Leukocyte cell-derived chemotaxin 1

LECT1_HUMAN » Leukocyte cell-derived chemotaxin 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LECT1_HUMAN » Leukocyte cell-derived chemotaxin 1 »
Hydrophobic Thickness 34.0 ± 0.8 Å
Tilt Angle 46 ± 0°
ΔGtransfer -29.1 kcal/mol
ΔGfold -17.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 36-64 (36-68)
Pathways none
PDB none
OPM none
Complexes none
Interactions

FURIN, Complex: FURIN:LECT1, PubMed

ROBO3, Complex: Very large complex, PubMed

Domains

AA: 106-200, PDBID: 2YAD, Subunit F, Seq Identity:23%, BRICHOS domain

UniProt annotation for LECT1_HUMAN » Leukocyte cell-derived chemotaxin 1
FUNCTION: Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.

TISSUE SPECIFICITY: Detected in cartilage and cardiac valves (at protein level). Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level). Expression is decreased cardiac valves of patients with valvular heart disease (at protein level). Weakly expressed in chondrosarcoma.

DEVELOPMENTAL STAGE: Expressed at 9 weeks in developing cartilagenous bone rudiments.

UniProt features for LECT1_HUMAN » Leukocyte cell-derived chemotaxin 1
CHAIN 1 210 Chondrosurfactant protein (By similarity).
PROPEP 211 214 Potential.
CHAIN 215 334 Chondromodulin-1.
DOMAIN 104 201 BRICHOS.
DISULFID 282 286 By similarity.
DISULFID 283 323 By similarity.
Amino Acid Sequence for LECT1_HUMAN » Leukocyte cell-derived chemotaxin 1
MTENSDKVPI ALVGPDDVEF CSPPAYATLT VKPSSPARLL KVGAVVLISG AVLLLFGAIG AFYFWKGSDS HIYNVHYTMS INGKLQDGSM EIDAGNNLET FKMGSGAEEA IAVNDFQNGI TGIRFAGGEK CYIKAQVKAR IPEVGAVTKQ SISSKLEGKI MPVKYEENSL IWVAVDQPVK DNSFLSSKVL ELCGDLPIFW LKPTYPKEIQ RERREVVRKI VPTTTKRPHS GPRSNPGAGR LNNETRPSVQ EDSQAFNPDN PYHQQEGESM TFDPRLDHEG ICCIECRRSY THCQKICEPL GGYYPWPYNY QGCRSACRVI MPCSWWVARI LGMV