LAYN_HUMAN » Layilin

LAYN_HUMAN » Layilin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LAYN_HUMAN » Layilin »
Hydrophobic Thickness 35.2 ± 4.4 Å
Tilt Angle 28 ± 1°
ΔGtransfer -27.2 kcal/mol
ΔGfold -21.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 233-259 (228-265)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 60-186, PDBID: 5AO5, Subunit A, Seq Identity:32%, Lectin C-type domain

UniProt annotation for LAYN_HUMAN » Layilin
FUNCTION: Receptor for hyaluronate.

SUBUNIT: Interacts with NF2, RDX and TLN1.

DOMAIN: The C-terminal domain interacts with the N-terminal domain of RDX.

UniProt features for LAYN_HUMAN » Layilin
SIGNAL 1 21 Potential.
CHAIN 22 382 Layilin.
DOMAIN 45 185 C-type lectin.
REPEAT 340 344 1-1.
REPEAT 350 354 1-2.
REPEAT 356 359 2-1.
REPEAT 371 375 1-3.
REPEAT 377 380 2-2.
REGION 330 374 Interaction with NF2 (By similarity).
REGION 337 382 Interaction with TLN1 (By similarity).
REGION 340 375 3 X 5 AA repeats of E-S-G-X-V.
REGION 356 380 2 X 4 AA repeats of N-X-I-Y.
DISULFID 71 184 By similarity.
DISULFID 150 176 By similarity.
Amino Acid Sequence for LAYN_HUMAN » Layilin
MRPGTALQAV LLAVLLVGLR AATGRLLSAS DLDLRGGQPV CRGGTQRPCY KVIYFHDTSR RLNFEEAKEA CRRDGGQLVS IESEDEQKLI EKFIENLLPS DGDFWIGLRR REEKQSNSTA CQDLYAWTDG SISQFRNWYV DEPSCGSEVC VVMYHQPSAP AGIGGPYMFQ WNDDRCNMKN NFICKYSDEK PAVPSREAEG EETELTTPVL PEETQEEDAK KTFKESREAA LNLAYILIPS IPLLLLLVVT TVVCWVWICR KRKREQPDPS TKKQHTIWPS PHQGNSPDLE VYNVIRKQSE ADLAETRPDL KNISFRVCSG EATPDDMSCD YDNMAVNPSE SGFVTLVSVE SGFVTNDIYE FSPDQMGRSK ESGWVENEIY GY