LAX1_HUMAN » Lymphocyte transmembrane adapter 1

LAX1_HUMAN » Lymphocyte transmembrane adapter 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LAX1_HUMAN » Lymphocyte transmembrane adapter 1 » Linker for activation of X cells;Membrane-associated adapter protein LAX;
Hydrophobic Thickness 34.4 ± 3.4 Å
Tilt Angle 15 ± 6°
ΔGtransfer -27.5 kcal/mol
ΔGfold -23.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 38-62 (32-67)
Pathways

Plant hormone signal transduction (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 28-398, Lymphocyte activation family X

UniProt annotation for LAX1_HUMAN » Lymphocyte transmembrane adapter 1
FUNCTION: Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells.

SUBUNIT: When phosphorylated, interacts with GRB2, PIK3R1 and GRAP2.

TISSUE SPECIFICITY: Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines.

INDUCTION: Up-regulated in T-cells following TCR engagement.

UniProt features for LAX1_HUMAN » Lymphocyte transmembrane adapter 1
CHAIN 1 398 Lymphocyte transmembrane adapter 1.
Amino Acid Sequence for LAX1_HUMAN » Lymphocyte transmembrane adapter 1
MDGVTPTLST IRGRTLESST LHVTPRSLDR NKDQITNIFS GFAGLLAILL VVAVFCILWN WNKRKKRQVP YLRVTVMPLL TLPQTRQRAK NIYDILPWRQ EDLGRHESRS MRIFSTESLL SRNSESPEHV PSQAGNAFQE HTAHIHATEY AVGIYDNAMV PQMCGNLTPS AHCINVRASR DCASISSEDS HDYVNVPTAE EIAETLASTK SPSRNLFVLP STQKLEFTEE RDEGCGDAGD CTSLYSPGAE DSDSLSNGEG SSQISNDYVN MTGLDLSAIQ ERQLWVAFQC CRDYENVPAA DPSGSQQQAE KDVPSSNIGH VEDKTDDPGT HVQCVKRTFL ASGDYADFQP FTQSEDSQMK HREEMSNEDS SDYENVLTAK LGGRDSEQGP GTQLLPDE