LAT_HUMAN » Linker for activation of T-cells family member 1

LAT_HUMAN » Linker for activation of T-cells family member 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LAT_HUMAN » Linker for activation of T-cells family member 1 » 36 kDa phospho-tyrosine adapter protein;pp36; p36-38;
Hydrophobic Thickness 34.4 ± 5.6 Å
Tilt Angle 29 ± 10°
ΔGtransfer -26.8 kcal/mol
ΔGfold -17.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 2-27 (2-32)
Pathways

aspartate degradation II (BioCyc)

CDP-diacylglycerol biosynthesis I (BioCyc)

Fc epsilon RI signaling pathway (KEGG)

Fc gamma R-mediated phagocytosis (KEGG)

Hemostasis (Reactome)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

NF-kappa B signaling pathway (KEGG)

phosphatidylglycerol biosynthesis II (non-plastidic) (BioCyc)

pyruvate decarboxylation to acetyl CoA (BioCyc)

T cell receptor signaling pathway (KEGG)

triacylglycerol biosynthesis (BioCyc)

PDB none
OPM none
Complexes none
Interactions

CD244, Complex: CD244:LAT, PubMed

CD3E, Complex: LAT:CD3E, PubMed

CD3Z, Complex: LAT:CD3Z, PubMed

CD4, Complex: LAT:CD4, PubMed

CD8A, Complex: CD8A:LAT, PubMed

CREB3, Complex: LAT:CREB3

EGFR, Complex: LAT:EGFR, PubMed

FCERG, Complex: LCP2:LAT:LYN:FCERG:PLCG2:GRB2:KSYK, PubMed

FCG2A, Complex: FCG2A:LAT, PubMed

FCGR1, Complex: FCGR1:LAT, PubMed

PTPRJ, Complex: PTPRJ:LAT, PubMed

UBP19, Complex: LAT:UBP19, PubMed

Domains

AA: 1-262, Linker for activation of T-cells

UniProt annotation for LAT_HUMAN » Linker for activation of T-cells family member 1
FUNCTION: Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

SUBUNIT: When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK (By similarity). Interacts with FCGR1A. Interacts with GRB2, PLCG1 and THEMIS upon TCR activation in thymocytes (By similarity).

TISSUE SPECIFICITY: Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).

MISCELLANEOUS: Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell- induced activation of PLC, maybe by inducing the dephosphorylation of LAT.

UniProt features for LAT_HUMAN » Linker for activation of T-cells family member 1
CHAIN 1 262 Linker for activation of T-cells family member 1.
REGION 161 164 Interaction with PLCG1.
REGION 200 203 Interaction with GRB2, GRAP2 and PIK3R1.
REGION 220 223 Interaction with GRB2, GRAP2 and PIK3R1.
Amino Acid Sequence for LAT_HUMAN » Linker for activation of T-cells family member 1
MEEAILVPCV LGLLLLPILA MLMALCVHCH RLPGSYDSTS SDSLYPRGIQ FKRPHTVAPW PPAYPPVTSY PPLSQPDLLP IPRSPQPLGG SHRTPSSRRD SDGANSVASY ENEGASGIRG AQAGWGVWGP SWTRLTPVSL PPEPACEDAD EDEDDYHNPG YLVVLPDSTP ATSTAAPSAP ALSTPGIRDS AFSMESIDDY VNVPESGESA EASLDGSREY VNVSQELHPG AAKTEPAALS SQEAEEVEEE GAPDYENLQE LN