LAP2B_HUMAN » Lamina-associated polypeptide 2, isoforms beta/gamma

LAP2B_HUMAN » Lamina-associated polypeptide 2, isoforms beta/gamma
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Topology in Nuclear inner membrane
Topologyintermembrane space
nucleus matrix side
LAP2B_HUMAN » Lamina-associated polypeptide 2, isoforms beta/gamma » Thymopoietin, isoforms beta/gamma;TP beta/gamma; Thymopoietin-related peptide isoforms beta/gamma;TPRP isoforms beta/gamma;
Hydrophobic Thickness 33.0 ± 1.2 Å
Tilt Angle 23 ± 0°
ΔGtransfer -26.8 kcal/mol
ΔGfold -22.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 412-434 (412-435)
Pathways

Cell Cycle (Reactome)

Mitotic M-M/G1 phases (Reactome)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 2-49, PDBID: 1GJJ, Subunit A, Seq Identity:100%, Thymopoietin protein

AA: 111-150, PDBID: 1GJJ, Subunit A, Seq Identity:100%, LEM domain

UniProt annotation for LAP2B_HUMAN » Lamina-associated polypeptide 2, isoforms beta/gamma
FUNCTION: May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.

FUNCTION: Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

SUBUNIT: Interacts with LMNB1, LMNB2, BANF1, AKAP8L, GMCL and chromosomes (By similarity). Isoform Zeta interacts with BANF1/BAF and may sequester it in the cytoplasm.

TISSUE SPECIFICITY: Expressed in many tissues. Most abundant in adult thymus and fetal liver.

DOMAIN: Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.

UniProt features for LAP2B_HUMAN » Lamina-associated polypeptide 2, isoforms beta/gamma
CHAIN 1 454 Lamina-associated polypeptide 2, isoforms beta/gamma.
PEPTIDE 1 50 Thymopoietin.
PEPTIDE 33 37 Thymopentin.
DOMAIN 5 48 LEM-like.
DOMAIN 109 153 LEM.
REGION 1 410 Nucleoplasmic (Potential).
REGION 49 108 Linker.
REGION 138 243 NAKAP95-binding N.
REGION 299 371 Binds lamins B.
REGION 300 374 NAKAP95-binding C.
Amino Acid Sequence for LAP2B_HUMAN » Lamina-associated polypeptide 2, isoforms beta/gamma
MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR PPLPAGTNSK GPPDFSSDEE REPTPVLGSG AAAAGRSRAA VGRKATKKTD KPRQEDKDDL DVTELTNEDL LDQLVKYGVN PGPIVGTTRK LYEKKLLKLR EQGTESRSST PLPTISSSAE NTRQNGSNDS DRYSDNEEDS KIELKLEKRE PLKGRAKTPV TLKQRRVEHN QSYSQAGITE TEWTSGSSKG GPLQALTRES TRGSRRTPRK RVETSEHFRI DGPVISESTP IAETIMASSN ESLVVNRVTG NFKHASPILP ITEFSDIPRR APKKPLTRAE VGEKTEERRV ERDILKEMFP YEASTPTGIS ASCRRPIKGA AGRPLELSDF RMEESFSSKY VPKYVPLADV KSEKTKKGRS IPVWIKILLF VVVAVFLFLV YQAMETNQVN PFSNFLHVDP RKSN