LAMP5_HUMAN » Lysosome-associated membrane glycoprotein 5

LAMP5_HUMAN » Lysosome-associated membrane glycoprotein 5
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Topology in Lysosomal membrane
Topologylysosome lumenal side
cytoplasmic side
LAMP5_HUMAN » Lysosome-associated membrane glycoprotein 5 » Brain and dendritic cell-associated LAMP;Brain-associated LAMP-like protein;BAD-LAMP; Lysosome-associated membrane protein 5;LAMP-5;
Hydrophobic Thickness 33.2 ± 1.6 Å
Tilt Angle 1 ± 2°
ΔGtransfer -25.6 kcal/mol
ΔGfold -19.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 236-258 (236-260)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-268, PDBID: 4AKM, Subunit B, Seq Identity:16%, Lysosome-associated membrane glycoprotein (Lamp)

UniProt annotation for LAMP5_HUMAN » Lysosome-associated membrane glycoprotein 5
TISSUE SPECIFICITY: Expressed in plasmocytoid dendritic cells. Expressed in suprabasal skin keratinocytes and squamous cells (at protein level). Expressed in the brain and weakly in spleen and skin. Expressed in plasmocytoid dendritic cells.

INDUCTION: Up-regulated upon CpG dinucleotides activation. Down- regulated upon activation by Toll-like receptor (TLR) ligands.

MISCELLANEOUS: Appears to be a novel specific biomarker for blastic plasmocytoid dendritic cells neoplasia.

UniProt features for LAMP5_HUMAN » Lysosome-associated membrane glycoprotein 5
SIGNAL 1 29 Potential.
CHAIN 30 280 Lysosome-associated membrane glycoprotein 5.
Amino Acid Sequence for LAMP5_HUMAN » Lysosome-associated membrane glycoprotein 5
MDLQGRGVPS IDRLRVLLML FHTMAQIMAE QEVENLSGLS TNPEKDIFVV RENGTTCLMA EFAAKFIVPY DVWASNYVDL ITEQADIALT RGAEVKGRCG HSQSELQVFW VDRAYALKML FVKESHNMSK GPEATWRLSK VQFVYDSSEK THFKDAVSAG KHTANSHHLS ALVTPAGKSY ECQAQQTISL ASSDPQKTVT MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI LGLILGLVIM VTLAIYHVHH KMTANQVQIP RDRSQYKHMG