LAMP3_HUMAN » Lysosome-associated membrane glycoprotein 3

LAMP3_HUMAN » Lysosome-associated membrane glycoprotein 3
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Topology in Lysosomal membrane
Topologylysosome lumenal side
cytoplasmic side
LAMP3_HUMAN » Lysosome-associated membrane glycoprotein 3 » Lysosomal-associated membrane protein 3;LAMP-3; DC-lysosome-associated membrane glycoprotein;DC LAMP; Protein TSC403;
Hydrophobic Thickness 32.4 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -34.1 kcal/mol
ΔGfold -15.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 379-404 (378-407)
Pathways

Lysosome (KEGG)

PDB 4akm (222-381)
OPM none
Complexes none
Interactions none
Domains

AA: 124-416, PDBID: 4AKM, Subunit B, Seq Identity:100%, Lysosome-associated membrane glycoprotein (Lamp)

UniProt annotation for LAMP3_HUMAN » Lysosome-associated membrane glycoprotein 3
FUNCTION: May play a role in dendritic cell function and in adaptive immunity.

SUBUNIT: Monomer.

TISSUE SPECIFICITY: Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer"s patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.

DEVELOPMENTAL STAGE: Up-regulated during dendritic cell maturation.

UniProt features for LAMP3_HUMAN » Lysosome-associated membrane glycoprotein 3
SIGNAL 1 27 Potential.
CHAIN 28 416 Lysosome-associated membrane glycoprotein 3.
DISULFID 237 274
DISULFID 339 376
Amino Acid Sequence for LAMP3_HUMAN » Lysosome-associated membrane glycoprotein 3
MPRQLSAAAA LFASLAVILH DGSQMRAKAF PETRDYSQPT AAATVQDIKK PVQQPAKQAP HQTLAARFMD GHITFQTAAT VKIPTTTPAT TKNTATTSPI TYTLVTTQAT PNNSHTAPPV TEVTVGPSLA PYSLPPTITP PAHTTGTSSS TVSHTTGNTT QPSNQTTLPA TLSIALHKST TGQKPVQPTH APGTTAAAHN TTRTAAPAST VPGPTLAPQP SSVKTGIYQV LNGSRLCIKA EMGIQLIVQD KESVFSPRRY FNIDPNATQA SGNCGTRKSN LLLNFQGGFV NLTFTKDEES YYISEVGAYL TVSDPETIYQ GIKHAVVMFQ TAVGHSFKCV SEQSLQLSAH LQVKTTDVQL QAFDFEDDHF GNVDECSSDY TIVLPVIGAI VVGLCLMGMG VYKIRLRCQS SGYQRI