LAMP2_HUMAN » Lysosome-associated membrane glycoprotein 2

LAMP2_HUMAN » Lysosome-associated membrane glycoprotein 2
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Topology in Lysosomal membrane
Topologylysosome lumenal side
cytoplasmic side
LAMP2_HUMAN » Lysosome-associated membrane glycoprotein 2 » LAMP-2; Lysosome-associated membrane protein 2; CD107 antigen-like family member B;
Hydrophobic Thickness 32.4 ± 2.0 Å
Tilt Angle 0 ± 3°
ΔGtransfer -43.6 kcal/mol
ΔGfold -21.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 375-398 (372-401)
Pathways

Hemostasis (Reactome)

Lysosome (KEGG)

Phagosome (KEGG)

Tuberculosis (KEGG)

PDB 2mof (369-410), 2mom (A/B/C=369-410)
OPM 2mof, 2mom
Complexes

LAMP2:LAMP2_HUMAN

Interactions

LAMP2, Complex: Transmembrane trimer of lysosome-associated glycoprotein 2, PDBID: 2MOM

NICA, Complex: NICA:LAMP2, PubMed

RNF13, Complex: RNF13:LAMP2, PubMed

TNFA, Complex: TNFA:LAMP2

Domains

AA: 110-410, PDBID: 2MOF, Subunit A, Seq Identity:100%, Lysosome-associated membrane glycoprotein (Lamp)

UniProt annotation for LAMP2_HUMAN » Lysosome-associated membrane glycoprotein 2
FUNCTION: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.

TISSUE SPECIFICITY: Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.

DISEASE: Danon disease (DAND) OMIM: DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. mutations affecting the gene represented in this entry.

UniProt features for LAMP2_HUMAN » Lysosome-associated membrane glycoprotein 2
SIGNAL 1 28
CHAIN 29 410 Lysosome-associated membrane glycoprotein 2.
REGION 29 192 First lumenal domain.
REGION 193 228 Hinge.
REGION 229 375 Second lumenal domain.
DISULFID 41 79 By similarity.
DISULFID 153 189 By similarity.
DISULFID 232 265 By similarity.
DISULFID 331 368 By similarity.
Amino Acid Sequence for LAMP2_HUMAN » Lysosome-associated membrane glycoprotein 2
MVCFRLFPVP GSGLVLVCLV LGAVRSYALE LNLTDSENAT CLYAKWQMNF TVRYETTNKT YKTVTISDHG TVTYNGSICG DDQNGPKIAV QFGPGFSWIA NFTKAASTYS IDSVSFSYNT GDNTTFPDAE DKGILTVDEL LAIRIPLNDL FRCNSLSTLE KNDVVQHYWD VLVQAFVQNG TVSTNEFLCD KDKTSTVAPT IHTTVPSPTT TPTPKEKPEA GTYSVNNGND TCLLATMGLQ LNITQDKVAS VININPNTTH STGSCRSHTA LLRLNSSTIK YLDFVFAVKN ENRFYLKEVN ISMYLVNGSV FSIANNNLSY WDAPLGSSYM CNKEQTVSVS GAFQINTFDL RVQPFNVTQG KYSTAQDCSA DDDNFLVPIA VGAALAGVLI LVLLAYFIGL KHHHAGYEQF