LAMP1_HUMAN » Lysosome-associated membrane glycoprotein 1

LAMP1_HUMAN » Lysosome-associated membrane glycoprotein 1
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Topology in Lysosomal membrane
Topologylysosome lumenal side
cytoplasmic side
LAMP1_HUMAN » Lysosome-associated membrane glycoprotein 1 » LAMP-1; Lysosome-associated membrane protein 1; CD107 antigen-like family member A;
Hydrophobic Thickness 34.4 ± 4.2 Å
Tilt Angle 0 ± 4°
ΔGtransfer -22.9 kcal/mol
ΔGfold -19.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 382-405 (379-410)
Pathways

Lysosome (KEGG)

Phagosome (KEGG)

Tuberculosis (KEGG)
PDB none
OPM none
Complexes none
Interactions

ALG2, Complex: ALG2:LAMP1, PubMed

EGFR, Complex: EGFR:LAMP1

NICA, Complex: LAMP1:NICA, PubMed
Domains

AA: 112-417, PDBID: 2MOF, Subunit A, Seq Identity:35%, Lysosome-associated membrane glycoprotein (Lamp)
UniProt annotation for LAMP1_HUMAN » Lysosome-associated membrane glycoprotein 1
FUNCTION: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

SUBUNIT: Interacts with Lassa virus protein GPC; this interaction allows virus entry.

UniProt features for LAMP1_HUMAN » Lysosome-associated membrane glycoprotein 1
SIGNAL 1 28
CHAIN 29 417 Lysosome-associated membrane glycoprotein 1.
REGION 29 194 First lumenal domain.
REGION 195 227 Hinge.
REGION 228 382 Second lumenal domain.
DISULFID 41 80
DISULFID 155 191
DISULFID 231 269
DISULFID 338 375
Amino Acid Sequence for LAMP1_HUMAN » Lysosome-associated membrane glycoprotein 1
MAAPGSARRP LLLLLLLLLL GLMHCASAAM FMVKNGNGTA CIMANFSAAF SVNYDTKSGP KNMTFDLPSD ATVVLNRSSC GKENTSDPSL VIAFGRGHTL TLNFTRNATR YSVQLMSFVY NLSDTHLFPN ASSKEIKTVE SITDIRADID KKYRCVSGTQ VHMNNVTVTL HDATIQAYLS NSSFSRGETR CEQDRPSPTT APPAPPSPSP SPVPKSPSVD KYNVSGTNGT CLLASMGLQL NLTYERKDNT TVTRLLNINP NKTSASGSCG AHLVTLELHS EGTTVLLFQF GMNASSSRFF LQGIQLNTIL PDARDPAFKA ANGSLRALQA TVGNSYKCNA EEHVRVTKAF SVNIFKVWVQ AFKVEGGQFG SVEECLLDEN SMLIPIAVGG ALAGLVLIVL IAYLVGRKRS HAGYQTI